Polyacetylenes from Saposhnikovia divaricata and their anticancer activity

被引：1
|
作者：
Sun, Yan [1 ,2 ]
Liu, Yan [1 ,2 ]
Jiang, Peng [1 ,2 ]
Wang, Si-Yi [1 ,2 ]
Pan, Juan [1 ,2 ]
Guan, Wei [1 ,2 ]
Wang, Yu-Xuan [1 ,2 ]
Kuang, Hai-Xue [1 ,2 ]
Wang, Yan-Hong [1 ,2 ,3 ]
Yang, Bing-You [1 ,2 ,3 ]
机构：
[1] Heilongjiang Univ Chinese Med, Sch Pharm, Harbin, Peoples R China
[2] Minist Educ, Key Lab Basic & Applicat Res Beiyao, Harbin, Peoples R China
[3] Heilongjiang Univ Chinese Med, Sch Pharm, Via Heping Rd 24, Harbin 150000, Heilongjiang, Peoples R China
来源：
FITOTERAPIA | 2024年 / 174卷
基金：
中国国家自然科学基金;
关键词：
Saposhnikovia divaricata; Polyacetylenes; A549; HEPG2;
D O I：
10.1016/j.fitote.2024.105876
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC50 value of 11.66 mu M against HEPG2.
引用
收藏
页数：7
相关论文
共 50 条
  • [31] Research on the fourth generation of Saposhnikovia divaricata by XRF
    Guan, Ying
    Yang, La-Hu
    Ding, Xi-Feng
    Guo, Xi-Hua
    Zhu, Yan-Ying
    Shi, Jin-Shan
    Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis, 2008, 28 (05): : 1191 - 1193
  • [32] Cimifugin Mechanism of Action from Saposhnikovia divaricata in the Treatment of Atopic Dermatitis
    Chen, Meng-Meng
    Du, Wen-Xia
    Dong, Chen-Qing
    Gao, Jie
    Mu, De-Song
    Ma, Fang-Qi
    Li, Xue-Huan
    Li, Xing-Yi
    Qu, Lu
    REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2024, 34 (04): : 793 - 802
  • [33] Genuine identification for Saposhnikovia divaricata based on improved DenseNet
    Li D.
    Tang P.
    Zhang L.
    Lei Y.
    Liu S.
    Nongye Gongcheng Xuebao/Transactions of the Chinese Society of Agricultural Engineering, 2022, 38 (03): : 276 - 285
  • [34] Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium
    Wang, CN
    Shiao, YJ
    Kuo, YH
    Chen, CC
    Lin, YL
    PLANTA MEDICA, 2000, 66 (07) : 644 - 647
  • [35] Saposhnikovia divaricata-An Ethnopharmacological, Phytochemical and Pharmacological Review
    Yang, Min
    Wang, Cong-cong
    Wang, Wen-le
    Xu, Jian-ping
    Wang, Jie
    Zhang, Chun-hong
    Li, Min-hui
    CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2020, 26 (11) : 873 - 880
  • [36] Anti-proliferative and antioxidant activities of Saposhnikovia divaricata
    Tai, Joseph
    Cheung, Susan
    ONCOLOGY REPORTS, 2007, 18 (01) : 227 - 234
  • [37] Transcriptome analysis of Saposhnikovia divaricata and mining of bolting and flowering genes
    Zhang, Min
    Wang, Wenle
    Liu, Qian
    Zang, Erhuan
    Wu, Lijun
    Hu, Guofa
    Li, Minhui
    CHINESE HERBAL MEDICINES, 2023, 15 (04) : 574 - 587
  • [38] Transcriptome analysis of Saposhnikovia divaricata and mining of bolting and fowering genes
    Min Zhang
    Wenle Wang
    Qian Liu
    Erhuan Zang
    Lijun Wu
    Guofa Hu
    Minhui Li
    Chinese Herbal Medicines, 2023, (04) : 574 - 587
  • [39] Transcriptome analysis of Saposhnikovia divaricata and mining of bolting and fowering genes
    Min Zhang
    Wenle Wang
    Qian Liu
    Erhuan Zang
    Lijun Wu
    Guofa Hu
    Minhui Li
    Chinese Herbal Medicines, 2023, 15 (04) : 574 - 587
  • [40] Characterization of the complete plastome of Saposhnikovia divaricata (Turcz.) Schischk
    Li, Lingli
    Geng, Maolin
    Li, Yingsuo
    Xu, Zenglai
    Xu, Ming
    Li, Mimi
    MITOCHONDRIAL DNA PART B-RESOURCES, 2020, 5 (01): : 786 - 787
12345