Chemical constituents from the Saposhnikovia divaricata and their antiproliferative activity

被引：1

作者：

Sun, Yan ^{[1
]}

Liu, Yan ^{[1
]}

Yang, Rui ^{[2
]}

Wang, Si-Yi ^{[2
]}

Pan, Juan ^{[2
]}

Guan, Wei ^{[2
]}

Kuang, Hai-Xue ^{[2
]}

Wang, Yan-Hong ^{[1
]}

Yang, Bing-You ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Haerbin, Peoples R China

[2] Heilongjiang Univ Chinese Med, Key Lab Basic & Applicat Res Beiyao, Minist Educ, Harbin, Peoples R China

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2024年 / 79卷 / 9-10期

关键词：

Saposhnikovia divaricata; alkaloid; pentacyclic triterpenoid; LN229; A549; KAPPA-B; INHIBITOR; SAPONINS; L;

D O I：

10.1515/znc-2024-0009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nine compounds were isolated and identified from ethanolic extracts of Saposhnikovia divaricata, including one new alkaloid (1), one new pentacyclic triterpenoid (9), and seven known alkaloids (2-8). Structural elucidation of compounds 1 and 9 was established by 1D and 2D NMR spectra referring to the literature, together with high-resolution mass spectrometric analysis. All compounds were evaluated for antiproliferative activity against two cancer cell lines (LN229, A549) in vitro. Compounds (1-9) showed no significant antiproliferative activity.

引用

页码：285 / 290

页数：6

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