IDIOTYPIC CASCADES AFTER INJECTION OF THE MONOCLONAL-ANTIBODY OC125 - A STUDY IN A MOUSE MODEL - INDUCTION OF ANTIBODIES AGAINST OC125 AND CA-125 AFTER IMMUNIZATION WITH AN ANTI-CA-125 (MAB OC125) MONOCLONAL-ANTIBODY BY ACTIVATION OF THE IDIOTYPIC NETWORK

被引：0

作者：

SCHULTES, BC ^{[1
]}

REINSBERG, J ^{[1
]}

SCHLEBUSCH, H ^{[1
]}

OEHR, P ^{[1
]}

BIERSACK, HJ ^{[1
]}

KREBS, D ^{[1
]}

WAGNER, U ^{[1
]}

机构：

[1] UNIV BONN, ZENTRUM GEBURTSHILFE & FRAUENHEILKUNDE, D-53127 BONN, GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY | 1993年 / 31卷 / 07期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By immunization of mice with the anti-CA 125 monoclonal antibody OC125, we tried to induce antibodies directed against the tumour-associated antigen CA 125, via activation of the idiotypic network. Mice immunized by repeated administrations of F(ab')2-fragments of the OC125 antibody produced anti-idiotypic antibodies, imitating the original target antigen of the OC125. After induction of these anti-idiotypic antibodies (Ab2beta) a murine IgG-anti-CA 125 (Ab3) response was detected. The induction of idiotypic cascades offers the possibility of immunization against tumour-associated antigens, without using the original antigen and breaking antitumour tolerance.

引用

页码：427 / 432

页数：6