IDIOTYPIC CASCADES AFTER INJECTION OF THE MONOCLONAL-ANTIBODY OC125 - A STUDY IN A MOUSE MODEL - INDUCTION OF ANTIBODIES AGAINST OC125 AND CA-125 AFTER IMMUNIZATION WITH AN ANTI-CA-125 (MAB OC125) MONOCLONAL-ANTIBODY BY ACTIVATION OF THE IDIOTYPIC NETWORK

被引：0
|
作者：
SCHULTES, BC [1 ]
REINSBERG, J [1 ]
SCHLEBUSCH, H [1 ]
OEHR, P [1 ]
BIERSACK, HJ [1 ]
KREBS, D [1 ]
WAGNER, U [1 ]
机构：
[1] UNIV BONN, ZENTRUM GEBURTSHILFE & FRAUENHEILKUNDE, D-53127 BONN, GERMANY
来源：
EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY | 1993年 / 31卷 / 07期
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
By immunization of mice with the anti-CA 125 monoclonal antibody OC125, we tried to induce antibodies directed against the tumour-associated antigen CA 125, via activation of the idiotypic network. Mice immunized by repeated administrations of F(ab')2-fragments of the OC125 antibody produced anti-idiotypic antibodies, imitating the original target antigen of the OC125. After induction of these anti-idiotypic antibodies (Ab2beta) a murine IgG-anti-CA 125 (Ab3) response was detected. The induction of idiotypic cascades offers the possibility of immunization against tumour-associated antigens, without using the original antigen and breaking antitumour tolerance.
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页码：427 / 432
页数：6
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