IDIOTYPIC CASCADES AFTER INJECTION OF THE MONOCLONAL-ANTIBODY OC125 - A STUDY IN A MOUSE MODEL - INDUCTION OF ANTIBODIES AGAINST OC125 AND CA-125 AFTER IMMUNIZATION WITH AN ANTI-CA-125 (MAB OC125) MONOCLONAL-ANTIBODY BY ACTIVATION OF THE IDIOTYPIC NETWORK

被引：0

作者：

SCHULTES, BC ^{[1
]}

REINSBERG, J ^{[1
]}

SCHLEBUSCH, H ^{[1
]}

OEHR, P ^{[1
]}

BIERSACK, HJ ^{[1
]}

KREBS, D ^{[1
]}

WAGNER, U ^{[1
]}

机构：

[1] UNIV BONN, ZENTRUM GEBURTSHILFE & FRAUENHEILKUNDE, D-53127 BONN, GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY | 1993年 / 31卷 / 07期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By immunization of mice with the anti-CA 125 monoclonal antibody OC125, we tried to induce antibodies directed against the tumour-associated antigen CA 125, via activation of the idiotypic network. Mice immunized by repeated administrations of F(ab')2-fragments of the OC125 antibody produced anti-idiotypic antibodies, imitating the original target antigen of the OC125. After induction of these anti-idiotypic antibodies (Ab2beta) a murine IgG-anti-CA 125 (Ab3) response was detected. The induction of idiotypic cascades offers the possibility of immunization against tumour-associated antigens, without using the original antigen and breaking antitumour tolerance.

引用

页码：427 / 432

页数：6

共 41 条

[21] INFLUENCE OF HUMAN ANTIMURINE ANTIBODY ON CA 125 LEVELS IN PATIENTS WITH OVARIAN-CANCER UNDERGOING RADIOIMMUNOTHERAPY OR IMMUNOSCINTIGRAPHY WITH MURINE MONOCLONAL-ANTIBODY OC 125
MUTO, MG
LEPISTO, EM
VANDENABBEELE, AD
KNAPP, RC
KASSIS, AI
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 161 (05) : 1206 - 1212
[22] A STUDY OF THE MONOCLONAL-ANTIBODY OC-125 TO DIAGNOSE MALIGNANT OVARIAN-TUMORS
LI, XG
CHEN, DX
SCHWARTZ, PE
YANG, Z
GYNECOLOGIC ONCOLOGY, 1989, 32 (03) : 327 - 330
[23] A HUMAN MOUSE CHIMERIC MONOCLONAL-ANTIBODY AGAINST CA-125 FOR RADIOIMMUNOIMAGING OF OVARIAN-CANCER
KOBAYASHI, H
SAKAHARA, H
SAGA, T
HOSONO, M
SHIRATO, M
KANDA, H
ISHIBASHI, K
WATANABE, T
ENDO, K
ISHIWATA, I
KONISHI, J
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1993, 37 (03) : 143 - 149
[24] DISTRIBUTION AND PHARMACOKINETICS OF RADIOLABELED MONOCLONAL-ANTIBODY OC-125 AFTER INTRAVENOUS AND INTRAPERITONEAL ADMINISTRATION IN GYNECOLOGIC TUMORS
HAISMA, HJ
MOSELEY, KR
BATTAILE, A
GRIFFITHS, TC
KNAPP, RC
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 159 (04) : 843 - 848
[25] MONITORING CANCER ANTIGEN-125 IN SERUM OF OVARIAN-CANCER PATIENTS AFTER ADMINISTRATION OF I-131-LABELED F(AB')2 FRAGMENTS OF OC125 ANTIBODY
REINSBERG, J
SCHULTES, B
WAGNER, U
KREBS, D
CLINICAL CHEMISTRY, 1993, 39 (05) : 891 - 896
[26] PROSPECTIVE RADIOIMMUNOSCINTIGRAPHIC DETECTION OF OVARIAN-CARCINOMA, ITS METASTASES AND ITS RECURRENCE USING I-131-LABLED AND IN-111-LABELED MONOCLONAL-ANTIBODY FRAGMENTS TO CA-12-5 (OC125)
BARES, R
WEILLER, G
FENDEL, H
SCHORSCH, M
BULL, U
NUKLEARMEDIZIN, 1988, 27 (02) : 8 - 8
[27] BIODISTRIBUTION OF IN-111 OC 125 MONOCLONAL-ANTIBODY (MAB) IN A NUDE-MOUSE MODEL INTRAPERITONEALLY (IP) GRAFTED WITH A HUMAN OVARIAN-CARCINOMA
THEDREZ, P
KREMER, M
CURTET, C
SAI, C
GUERREAU, D
SACCAVINI, JC
CHATAL, JF
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1988, 14 (5-6): : 240 - 240
[28] INTRAVENOUS VERSUS INTRAPERITONEAL INJECTION OF I-131-OC 125 MONOCLONAL-ANTIBODY IN NUDE-MICE WITH PERITONEAL CARCINOSIS
SENEKOWITSCH, R
SCHMID, P
BAUM, RP
MOLLENSTADT, S
KRIEGEL, H
PABST, HW
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1988, 14 (7-8): : C3 - C3
[29] INCREASED CA125 ELEVATION IN PATIENTS AFTER ADMINISTRATION OF I-131-OC125 CAUSED BY HUMAN ANTI-MOUSE ANTIBODIES
HAISMA, HJ
MOSELEY, KR
KNAPP, RC
BOVEN, E
PINEDO, HM
BRITISH JOURNAL OF CANCER, 1989, 59 (02) : 316 - 317
[30] TUMOR-MARKERS FOR OVARIAN-CANCER - A COMPARATIVE IMMUNOHISTOCHEMICAL AND IMMUNOCYTOCHEMICAL STUDY OF 2 COMMERCIAL MONOCLONAL-ANTIBODIES (OV632 AND OC125)
KOELMA, IA
NAP, M
VANSTEENIS, GJ
FLEUREN, GJ
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1988, 90 (04) : 391 - 396

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