3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methyl}aniline

被引：3
|
作者：
Bawa, Sandhya [1 ]
Ahmad, Fasih [1 ]
Kumar, Suresh [1 ]
机构：
[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
MOLBANK | 2009年 / 04期
关键词：
reductive amination; pyrazolylamine; NaBH4/I-2;
D O I：
10.3390/M640
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH4/I-2 as a reducing agent is described. The reaction was carried out in MeOH under neutral conditions at room temperature to give the secondary amine, 3-chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]methyl} aniline (3).
引用
收藏
页数：4
相关论文
共 50 条
  • [31] Diethyl 2-[(3,5-dimethyl-1H-pyrazol-1-yl)(4-methoxyphenyl)methyl]propanedioate
    Meskini, Ihssan
    Daoudi, Maria
    Daran, Jean-Claude
    Kerbal, Abdelali
    Zouihri, Hafid
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1965 - U736
  • [32] Synthesis and crystal structure of 2(1-phenyl-3-methyl-5-chloro-1H-pyrazol-4-yl)-3-(1-naphthoylamido)-4-thiazolidinone
    Li, M
    Wen, LR
    Jing, SX
    Zhao, GL
    Yang, ZH
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2004, 23 (04) : 366 - 370
  • [33] [4-(4-Methoxyphenyl)-1-methyl-3-nitropyrrolidin-3-yl]methanol
    Prathebha, K.
    Sathya, S.
    Usha, G.
    Siyakumar, N.
    Bakthadoss, M.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O372 - +
  • [34] 1H and 13C NMR spectral assignment of 29 N′-(3-([1,1′-biphenyl]-4-yl)-1-phenyl-1H-pyrazol-4-yl)acylhydrazones
    Park, Jihyun
    Ahn, Seunghyun
    Lee, Youngshim
    Koh, Dongsoo
    Lim, Yoongho
    MAGNETIC RESONANCE IN CHEMISTRY, 2021, 59 (06) : 648 - 662
  • [35] 3-(4-chloro-phenyl-diazen-yl)-1-methyl-2-phenyl-1H-indole
    Seferoglu, Zeynel
    Hokelek, Tuncer
    Sahin, Ertan
    Ertan, Nermin
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O2108 - O2110
  • [36] 1-[5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone
    Abbas, Asghar
    Hussain, Safdar
    Hafeez, Noureen
    Lo, Kong Mun
    Hasan, Aurangzeb
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O3174 - U680
  • [37] N,N-dimethyl-4-[5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]-aniline
    Wang, Shu-Wen
    Zuo, Zheng-Quan
    Yang, Wen-Long
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O353 - U1555
  • [38] 4-[(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylideneamino]-1,5dimethyl-2-phenyl-1H-pyrazol-3(2H)one
    Zhu, Hualing
    Zhu, Jinhua
    Ban, Litong
    Zhang, Pingping
    Zhang, Miao
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2724 - U1784
  • [39] The 4-(Tris(4-methyl-1H-pyrazol-1-yl)methyl)aniline
    Garrison, Bradley B.
    Duhamel, Joseph E.
    Antoine, Nehemiah
    Symes, Steven J. K.
    Grice, Kyle A.
    McMillen, Colin D.
    Pienkos, Jared A.
    MOLBANK, 2024, 2024 (02)
  • [40] (E)-2-Methyl-6-[(1-phenyl-1H-pyrazol-4-yl)methylidene]cyclohexanone
    Asiri, Abdullah M.
    Faidallah, Hassan M.
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1611 - U2238
12345