3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methyl}aniline

被引：3
|
作者：
Bawa, Sandhya [1 ]
Ahmad, Fasih [1 ]
Kumar, Suresh [1 ]
机构：
[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
MOLBANK | 2009年 / 04期
关键词：
reductive amination; pyrazolylamine; NaBH4/I-2;
D O I：
10.3390/M640
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH4/I-2 as a reducing agent is described. The reaction was carried out in MeOH under neutral conditions at room temperature to give the secondary amine, 3-chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]methyl} aniline (3).
引用
收藏
页数：4
相关论文
共 50 条
  • [21] 1-(4-Methoxyphenyl)-3-phenyl-1H-pyrazol-5-amine
    Kumarasinghe, Isuru R.
    Hruby, Victor J.
    Nichol, Gary S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1170 - U3359
  • [22] N-[(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)carbonyl]-N′-(4-hydroxy-phenyl)thiourea
    Du, Haitang
    Du, Haijun
    An, Ying
    Li, Shengnan
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1404 - U1477
  • [23] Synthesis and antimicrobial activity of 4-[5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl]dihydropyridines and 4-[5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl]-3,4-dihydropyrimidin-2-ones
    Kumar, Rakesh
    Malik, Sakshi
    Chandra, Ramesh
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (05): : 718 - 724
  • [24] (2Z,5Z)-5-((3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-((4-methoxyphenyl)imino)-3-phenylthiazolidin-4-one
    Abdel-Wahab, Bakr F.
    Mohamed, Hanan A.
    Kariuki, Benson M.
    El-Hiti, Gamal A.
    MOLBANK, 2023, 2023 (02)
  • [25] 1-[3-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-ethanone
    Fun, Hoong-Kun
    Quah, Ching Kheng
    Samshuddin, S.
    Narayana, B.
    Sarojini, B. K.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1023 - +
  • [26] 2-(Benzoylamino)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)acrylic acid
    Kaushik, Darpan
    Verma, Tarawanti
    Madaan, Kapish
    MOLBANK, 2011, (02)
  • [27] Dimethyl [(5-chloro-1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carbonyloxy)(4-methoxyphenyl)-methyl]phosphonate
    Liang, Y
    He, HW
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O485 - O486
  • [28] SYNTHESIS OF SOME 2-(3-(4-ETHYLPHENYL)-1-PHENYL-1H-PYRAZOL-4-YL)) VINYL-4H-CHROMENE-4-ONES
    Thore, S. N.
    Gupta, Ashwini Kumar
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 19 (04) : 329 - 332
  • [29] 7-Chloro-2-[1-(4-methoxyphenyl)pyrazol-4-yl]-3,3-dimethyl-3H-indole
    Helliwell, Madeleine
    Afghan, Arash
    Keshvari, Foroogh
    Baradarani, Mehdi M.
    Joule, John A.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O112 - U2016
  • [30] (4-Chlorophenyl)[1-(4-methoxyphenyl)-3-(5-nitro-2-furyl)-1H-pyrazol-4-yl]methanone
    Goh, Jia Hao
    Fun, Hoong-Kun
    Nithinchandra
    Kalluraya, B.
    Rai, N. Satheesh
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1063 - U1680
12345