NERVE GROWTH FACTOR-INDUCED LOSS OF CELL-ASSOCIATED NERVE GROWTH-FACTOR RECEPTOR IN HUMAN-MELANOMA A875-CELLS

被引：4
|
作者：
HERTEL, C
SCHUBENEL, R
机构：
[1] Pharma Division, Preclinical Research, F. Hoffmann La Roche Ltd., Basel
来源：
NEUROSCIENCE LETTERS | 1992年 / 136卷 / 01期
关键词：
MELANOMA CELL; P75NGFR; RECEPTOR SHEDDING; IMMUNOPRECIPITATION;
D O I：
10.1016/0304-3940(92)90661-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Human A875 melanoma cells are known to express the low-affinity nerve growth factor receptor p75NGFR in a monomeric and a covalently linked probably dimeric form. Kinetic analysis of the association of nerve growth factor (NGF) with its receptor revealed a rapid loss of binding sites at high ligand concentrations. Using cross-linking and immunoprecipitation with an anti-p75NGFR antibody, this was found to be due to a decrease of the high molecular weight form of the receptor. Mechanisms for such a ligand-induced receptor loss are discussed.
引用
收藏
页码：113 / 117
页数：5
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