NERVE GROWTH FACTOR-INDUCED LOSS OF CELL-ASSOCIATED NERVE GROWTH-FACTOR RECEPTOR IN HUMAN-MELANOMA A875-CELLS

被引：4

作者：

HERTEL, C

SCHUBENEL, R

机构：

[1] Pharma Division, Preclinical Research, F. Hoffmann La Roche Ltd., Basel

来源：

NEUROSCIENCE LETTERS | 1992年 / 136卷 / 01期

关键词：

MELANOMA CELL; P75NGFR; RECEPTOR SHEDDING; IMMUNOPRECIPITATION;

D O I：

10.1016/0304-3940(92)90661-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human A875 melanoma cells are known to express the low-affinity nerve growth factor receptor p75NGFR in a monomeric and a covalently linked probably dimeric form. Kinetic analysis of the association of nerve growth factor (NGF) with its receptor revealed a rapid loss of binding sites at high ligand concentrations. Using cross-linking and immunoprecipitation with an anti-p75NGFR antibody, this was found to be due to a decrease of the high molecular weight form of the receptor. Mechanisms for such a ligand-induced receptor loss are discussed.

引用

页码：113 / 117

页数：5

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