INVESTIGATION INTO SPECIES VARIANTS IN TACHYKININ NK1 RECEPTORS BY USE OF THE NONPEPTIDE ANTAGONIST, CP-96,345

被引：229
|
作者：
BERESFORD, IJM
BIRCH, PJ
HAGAN, RM
IRELAND, SJ
机构：
[1] Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, SG12 0DP, Park Road
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 104卷 / 02期
关键词：
TACHYKININ NK1 RECEPTOR; NK1 RECEPTOR ANTAGONIST; SPECIES VARIANTS; SUBTYPE, CP-96,345;
D O I：
10.1111/j.1476-5381.1991.tb12423.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.
引用
收藏
页码：292 / 293
页数：2
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