INVESTIGATION INTO SPECIES VARIANTS IN TACHYKININ NK1 RECEPTORS BY USE OF THE NONPEPTIDE ANTAGONIST, CP-96,345

被引：229

作者：

BERESFORD, IJM

BIRCH, PJ

HAGAN, RM

IRELAND, SJ

机构：

[1] Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, SG12 0DP, Park Road

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 104卷 / 02期

关键词：

TACHYKININ NK1 RECEPTOR; NK1 RECEPTOR ANTAGONIST; SPECIES VARIANTS; SUBTYPE, CP-96,345;

D O I：

10.1111/j.1476-5381.1991.tb12423.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.

引用

页码：292 / 293

页数：2

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[31] IS THE SELECTIVE NONPEPTIDE NK-1 RECEPTOR ANTAGONIST CP96,345 A PERIPHERALLY ACTING ANALGESIC
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