INVESTIGATION INTO SPECIES VARIANTS IN TACHYKININ NK1 RECEPTORS BY USE OF THE NONPEPTIDE ANTAGONIST, CP-96,345

被引：229
|
作者：
BERESFORD, IJM
BIRCH, PJ
HAGAN, RM
IRELAND, SJ
机构：
[1] Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, SG12 0DP, Park Road
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 104卷 / 02期
关键词：
TACHYKININ NK1 RECEPTOR; NK1 RECEPTOR ANTAGONIST; SPECIES VARIANTS; SUBTYPE, CP-96,345;
D O I：
10.1111/j.1476-5381.1991.tb12423.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.
引用
收藏
页码：292 / 293
页数：2
相关论文
共 50 条
  • [1] CARDIOVASCULAR EFFECTS OF CP-96,345, A NONPEPTIDE BLOCKER OF TACHYKININ NK1 RECEPTORS
    KNIGHT, D
    BENOIT, P
    WOLFGANG, E
    LEBEL, W
    WOODY, H
    CONSTANTINE, J
    FASEB JOURNAL, 1994, 8 (05): : A884 - A884
  • [2] CARDIOVASCULAR EFFECTS OF CP-96,345, A NONPEPTIDE BLOCKER OF TACHYKININ NK1 RECEPTORS
    CONSTANTINE, JW
    LEBEL, WS
    WOODY, HA
    BENOIT, PA
    WOLFGANG, EA
    KNIGHT, DR
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 252 (03) : 275 - 282
  • [3] NONPEPTIDE ANTAGONISTS, CP-96,345 AND RP-67580, DISTINGUISH SPECIES VARIANTS IN TACHYKININ NK(1)-RECEPTORS
    BARR, AJ
    WATSON, SP
    BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (01) : 223 - 227
  • [4] AN SAR STUDY FOR THE NONPEPTIDE SUBSTANCE-P RECEPTOR (NK1) ANTAGONIST, CP-96,345
    HOWSON, W
    HODGSON, J
    RICHARDSON, R
    WALTON, L
    GUARD, S
    WATLING, K
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (06) : 559 - 564
  • [5] VENTILATORY RESPONSES TO HYPOXIA IN RATS PRETREATED WITH NONPEPTIDE NK1 RECEPTOR ANTAGONIST CP-96,345
    DESANCTIS, GT
    GREEN, FHY
    JIANG, X
    KING, M
    REMMERS, JE
    JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (04) : 1528 - 1532
  • [6] THE NONPEPTIDE TACHYKININ ANTAGONIST, CP-96,345, IS A POTENT INHIBITOR OF NEUROGENIC INFLAMMATION
    LEMBECK, F
    DONNERER, J
    TSUCHIYA, M
    NAGAHISA, A
    BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (03) : 527 - 530
  • [7] THE NONPEPTIDE NK1 RECEPTOR ANTAGONIST, (+/-)-CP-96,345, PRODUCES ANTINOCICEPTIVE AND ANTI-EDEMA EFFECTS IN THE RAT
    BIRCH, PJ
    HARRISON, SM
    HAYES, AG
    ROGERS, H
    TYERS, MB
    BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (03) : 508 - 510
  • [8] INTERACTION OF THE NONPEPTIDE NK1 TACHYKININ RECEPTOR ANTAGONIST (+/-)CP-96,345 WITH L-TYPE CALCIUM CHANNELS IN RAT CEREBRAL-CORTEX
    GUARD, S
    WATLING, KJ
    BRITISH JOURNAL OF PHARMACOLOGY, 1992, 106 : P37 - P37
  • [9] EFFECTS OF CP-96,345, A NOVEL NONPEPTIDE ANTAGONIST OF NK1 RECEPTOR, ON THE PERISTALSIS IN ISOLATED GUINEA-PIG ILEUM
    SUZUKI, N
    GOMI, Y
    JAPANESE JOURNAL OF PHARMACOLOGY, 1992, 58 (04): : 473 - 477
  • [10] ROLE OF NK1 TACHYKININ RECEPTORS IN THERMONOCICEPTION - EFFECT OF (+/-)-CP 96,345, A NONPEPTIDE SUBSTANCE-P ANTAGONIST, ON THE HOT PLATE TEST IN MICE
    LECCI, A
    GIULIANI, S
    PATACCHINI, R
    VITI, G
    MAGGI, CA
    NEUROSCIENCE LETTERS, 1991, 129 (02) : 299 - 302
12345