C-13 NMR EVIDENCE FOR 3 SLOWLY INTERCONVERTING CONFORMATIONS OF THE DIHYDROFOLATE REDUCTASE-NADP+-FOLATE COMPLEX

被引：18

作者：

BIRDSALL, B ^{[1
]}

GRONENBORN, A ^{[1
]}

CLORE, GM ^{[1
]}

ROBERTS, GCK ^{[1
]}

FEENEY, J ^{[1
]}

BURGEN, ASV ^{[1
]}

机构：

[1] NATL INST MED RES,DIV MOLEC PHARMACOL,LONDON NW7 1AA,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1981年 / 101卷 / 04期

关键词：

D O I：

10.1016/0006-291X(81)91566-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1139 / 1144

页数：6

共 18 条

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[2] BINDING OF COENZYME ANALOGS TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - BINARY AND TERNARY COMPLEXES [J].

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BURGEN, ASV ;

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[3]

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[4]

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[5] NUCLEAR MAGNETIC-RESONANCE STUDIES ON BACTERIAL DIHYDROFOLATE-REDUCTASE CONTAINING [GUANIDINO-C-13] ARGININE [J].

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[6] LARGE-SCALE PURIFICATION AND CHARACTERIZATION OF DIHYDROFOLATE-REDUCTASE FROM A METHOTREXATE-RESISTANT STRAIN OF LACTOBACILLUS-CASEI [J].

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[7] KINETICS OF LIGAND-BINDING TO DIHYDROFOLATE-REDUCTASE - BINARY COMPLEX-FORMATION WITH NADPH AND COENZYME ANALOGS [J].

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[8] H-1 NUCLEAR MAGNETIC-RESONANCE STUDIES OF TYROSINE RESIDUES OF SELECTIVELY DEUTERATED LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE [J].

FEENEY, J ;

ROBERTS, GCK ;

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BURGEN, A .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1977, 196 (1124) :267-290

[9] P-31 NMR-STUDIES OF NADPH AND NADP+ BINDING TO L-CASEI DIHYDROFOLATE-REDUCTASE [J].

FEENEY, J ;

BIRDSALL, B ;

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BURGEN, ASV .

NATURE, 1975, 257 (5527) :564-566

[10] DIRECT OBSERVATION BY NMR OF 2 COEXISTING CONFORMATIONS OF AN ENZYME-LIGAND COMPLEX IN SOLUTION [J].

GRONENBORN, A ;

BIRDSALL, B ;

HYDE, EI ;

ROBERTS, GCK ;

FEENEY, J ;

BURGEN, ASV .

NATURE, 1981, 290 (5803) :273-274

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