DIRECT OBSERVATION BY NMR OF 2 COEXISTING CONFORMATIONS OF AN ENZYME-LIGAND COMPLEX IN SOLUTION

被引：27

作者：

GRONENBORN, A ^{[1
]}

BIRDSALL, B ^{[1
]}

HYDE, EI ^{[1
]}

ROBERTS, GCK ^{[1
]}

FEENEY, J ^{[1
]}

BURGEN, ASV ^{[1
]}

机构：

[1] NATL INST MED RES,DIV MOLEC PHARMACOL,LONDON NW7 1AA,ENGLAND

来源：

NATURE | 1981年 / 290卷 / 5803期

关键词：

D O I：

10.1038/290273a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：273 / 274

页数：2

共 19 条

[1] ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE - ISOLATION AND CHARACTERIZATION OF 2 ISOZYMES [J].

BACCANARI, DP ;

AVERETT, D ;

BRIGGS, C ;

BURCHALL, J .

BIOCHEMISTRY, 1977, 16 (16) :3566-3572

[2] H-1 NUCLEAR MAGNETIC-RESONANCE STUDIES OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - EFFECTS OF SUBSTRATE AND INHIBITOR BINDING ON HISTIDINE RESIDUES [J].

BIRDSALL, B ;

GRIFFITHS, DV ;

ROBERTS, GCK ;

FEENEY, J ;

BURGEN, A .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1977, 196 (1124) :251-265

[3] COOPERATIVITY IN LIGAND-BINDING TO DIHYDROFOLATE-REDUCTASE [J].

BIRDSALL, B ;

BURGEN, ASV ;

MIRANDA, JRD ;

ROBERTS, GCK .

BIOCHEMISTRY, 1978, 17 (11) :2102-2110

[4] BINDING OF COENZYME ANALOGS TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - BINARY AND TERNARY COMPLEXES [J].

BIRDSALL, B ;

BURGEN, ASV ;

ROBERTS, GCK .

BIOCHEMISTRY, 1980, 19 (16) :3723-3731

[5] AMINO-ACID SEQUENCE OF DIHYDROFOLATE-REDUCTASE FROM AN AMETHOPTERIN-RESISTANT STRAIN OF LACTOBACILLUS-CASEI [J].

BITAR, KG ;

BLANKENSHIP, DT ;

WALSH, KA ;

DUNLAP, RB ;

REDDY, AV ;

FREISHEIM, JH .

FEBS LETTERS, 1977, 80 (01) :119-122

[6]

Blakley R. L., 1969, FRONT BIOL

[7]

BURCHALL JJ, 1965, MOL PHARMACOL, V1, P126

[8]

CAYLEY PJ, 1979, BIOCHEMISTRY-US, V18, P3886, DOI 10.1021/bi00585a008

[9] H-1 NUCLEAR MAGNETIC-RESONANCE STUDIES OF TYROSINE RESIDUES OF SELECTIVELY DEUTERATED LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE [J].

FEENEY, J ;

ROBERTS, GCK ;

BIRDSALL, B ;

GRIFFITHS, DV ;

KING, RW ;

SCUDDER, P ;

BURGEN, A .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1977, 196 (1124) :267-290

[10] PHOTO-CIDNP STUDIES OF THE INFLUENCE OF LIGAND-BINDING ON THE SURFACE ACCESSIBILITY OF AROMATIC RESIDUES IN DIHYDROFOLATE-REDUCTASE [J].

FEENEY, J ;

ROBERTS, GCK ;

KAPTEIN, R ;

BIRDSALL, B ;

GRONENBORN, A ;

BURGEN, ASV .

BIOCHEMISTRY, 1980, 19 (11) :2466-2472

← 1 2 →