NEUTROPHIL CHEMOTACTIC FACTOR PRODUCED BY JAPANESE ENCEPHALITIS-VIRUS STIMULATED MACROPHAGES

被引：0
|
作者：
KHANNA, N [1 ]
AGNIHOTRI, M [1 ]
MATHUR, A [1 ]
CHATURVEDI, UC [1 ]
机构：
[1] KING GEORGE V MEM HOSP,POSTGRAD DEPT MICROBIOL,LUCKNOW 226003,UTTAR PRADESH,INDIA
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1991年 / 86卷 / 02期
关键词：
JAPANESE ENCEPHALITIS VIRUS; NEUTROPHIL CHEMOTACTIC FACTOR; MACROPHAGE DERIVED CYTOKINE; NEUTROPHILIA;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mechanism of neutrophil leucocytosis in cases of Japanese encephalitis is not known, We here report that during Japanese encephalitis virus (JEV) infection in mice the splenic macrophages secrete a chemotactic factor that attracts the neutrophils. The peak activity of macrophage derived factor (MDF) was observed on day 7 following infection. The MDF acted in a dose-dependent manner. This chemoattractant was purified by low pressure liquid chromatography and gave a single band of 10 kD on silver stained polyacrylamide gel. The MDF was found to be heat resistant and sensitive to prolonged incubation with proteases.
引用
收藏
页码：299 / 303
页数：5
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