NEUTROPHIL CHEMOTACTIC FACTOR PRODUCED BY JAPANESE ENCEPHALITIS-VIRUS STIMULATED MACROPHAGES

被引：0

作者：

KHANNA, N ^{[1
]}

AGNIHOTRI, M ^{[1
]}

MATHUR, A ^{[1
]}

CHATURVEDI, UC ^{[1
]}

机构：

[1] KING GEORGE V MEM HOSP,POSTGRAD DEPT MICROBIOL,LUCKNOW 226003,UTTAR PRADESH,INDIA

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1991年 / 86卷 / 02期

关键词：

JAPANESE ENCEPHALITIS VIRUS; NEUTROPHIL CHEMOTACTIC FACTOR; MACROPHAGE DERIVED CYTOKINE; NEUTROPHILIA;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanism of neutrophil leucocytosis in cases of Japanese encephalitis is not known, We here report that during Japanese encephalitis virus (JEV) infection in mice the splenic macrophages secrete a chemotactic factor that attracts the neutrophils. The peak activity of macrophage derived factor (MDF) was observed on day 7 following infection. The MDF acted in a dose-dependent manner. This chemoattractant was purified by low pressure liquid chromatography and gave a single band of 10 kD on silver stained polyacrylamide gel. The MDF was found to be heat resistant and sensitive to prolonged incubation with proteases.

引用

页码：299 / 303

页数：5

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