TOTAL SYNTHESIS AND IONOPHORIC BEHAVIOR OF A GRAMICIDIN A ANALOG

被引：4
|
作者：
CALMES, M [1 ]
DAUNIS, J [1 ]
DAVID, D [1 ]
LAZARO, R [1 ]
机构：
[1] UNIV MONTPELLIER 2,CNRS,AMINOACIDES & PEPTIDES LAB,PL E BATAILLON,F-34095 MONTPELLIER 05,FRANCE
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 20期
关键词：
D O I：
10.1016/S0040-4039(00)73680-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new gramicidin A analogue (GAA) containing a C-terminal P-alaninamide group instead of the natural ethanolamine moiety has been synthesized on a polyacrylic resin and examined after its incorporation into a black lipid membrane (BLM). Preliminary conductance data show that this peptide and the natural gramicidin both display the same ionophoric activity.
引用
收藏
页码：3275 / 3278
页数：4
相关论文
共 50 条
  • [41] FORMATION OF ION CHANNELS BY A NEGATIVELY CHARGED ANALOG OF GRAMICIDIN-A
    APELL, HJ
    BAMBERG, E
    ALPES, H
    LAUGER, P
    JOURNAL OF MEMBRANE BIOLOGY, 1977, 31 (1-2): : 171 - 188
  • [42] THE SOURCE OF THE DISPERSITY OF GRAMICIDIN-A SINGLE-CHANNEL CONDUCTANCES - THE L.LEU5-GRAMICIDIN-A ANALOG
    URRY, DW
    ALONSOROMANOWSKI, S
    VENKATACHALAM, CM
    TRAPANE, TL
    PRASAD, KU
    BIOPHYSICAL JOURNAL, 1984, 46 (02) : 259 - 266
  • [43] Self control of gramicidin S synthesis by its product, gramicidin S
    Hori, K
    Kanoh, N
    Kurotsu, T
    FASEB JOURNAL, 1997, 11 (09): : A1018 - A1018
  • [44] EXPERIMENTAL AND THEORETICAL-STUDY OF GRAMICIDIN-P, AN ANALOG OF GRAMICIDIN-A WITH A METHYLAMINE-C-TERMINAL
    TRUDELLE, Y
    DAUMAS, P
    HEITZ, F
    ETCHEBEST, C
    PULLMAN, A
    FEBS LETTERS, 1987, 216 (01) : 11 - 16
  • [45] GRAMICIDIN A .6. SYNTHESIS OF VALINE- AND ISOLEUCINE-GRAMICIDIN A
    SARGES, R
    WITKOP, B
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (09) : 2020 - &
  • [46] SYNTHESIS OF ACYLATED GRAMICIDINS AND THE INFLUENCE OF ACYLATION ON THE INTERFACIAL PROPERTIES AND CONFORMATIONAL BEHAVIOR OF GRAMICIDIN-A
    VOGT, TCB
    KILLIAN, JA
    DEMEL, RA
    DEKRUIJFF, B
    BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1069 (02) : 157 - 164
  • [47] Enantioselective total synthesis of eurylene, 14-deacetyl eurylene, and their 11-epimers: The relation between ionophoric nature and cytotoxicity
    Hioki, H
    Yoshio, S
    Motosue, M
    Oshita, Y
    Nakamura, Y
    Mishima, D
    Fukuyama, Y
    Kodama, M
    Ueda, K
    Katsu, T
    ORGANIC LETTERS, 2004, 6 (06) : 961 - 964
  • [48] Bis(azobenzocrown ether)s-synthesis and ionophoric properties
    Szarmach, Miroslaw
    Wagner-Wysiecka, Ewa
    Fonari, Marina S.
    Luboch, Elzbieta
    TETRAHEDRON, 2012, 68 (02) : 507 - 515
  • [49] Characterization of gramicidin S synthetase aggregation substance: Control of gramicidin S synthesis by its product, gramicidin S
    Hori, K
    Kurotsu, T
    JOURNAL OF BIOCHEMISTRY, 1997, 122 (03): : 606 - 615
  • [50] NEW SYNTHETIC AND ANTIBIOTIC ANALOG OF GRAMICIDIN-S, [4-5-DELTA-AMINOVALERIC ACID]-GRAMICIDIN S
    MURAMATSU, I
    SOFUKU, S
    HAGITANI, A
    JOURNAL OF ANTIBIOTICS, 1972, 25 (03): : 189 - +
12345