TOTAL SYNTHESIS AND IONOPHORIC BEHAVIOR OF A GRAMICIDIN A ANALOG

被引:4
|
作者
CALMES, M [1 ]
DAUNIS, J [1 ]
DAVID, D [1 ]
LAZARO, R [1 ]
机构
[1] UNIV MONTPELLIER 2,CNRS,AMINOACIDES & PEPTIDES LAB,PL E BATAILLON,F-34095 MONTPELLIER 05,FRANCE
关键词
D O I
10.1016/S0040-4039(00)73680-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new gramicidin A analogue (GAA) containing a C-terminal P-alaninamide group instead of the natural ethanolamine moiety has been synthesized on a polyacrylic resin and examined after its incorporation into a black lipid membrane (BLM). Preliminary conductance data show that this peptide and the natural gramicidin both display the same ionophoric activity.
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页码:3275 / 3278
页数:4
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