共 44 条
- [41] Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yObenzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor Related Orphan Receptor C2 Inverse AgonistJOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (23) : 10415 - 10439Schnute, Mark E.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAWennerstal, Mattias论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAAlley, Jennifer论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USABengtsson, Martin论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USABlinn, James R.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Worldwide Med Chem, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USABolten, Charles W.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USABraden, Timothy论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USABonn, Tomas论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USACarlsson, Bo论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USACaspers, Nicole论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAChen, Ming论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAChoi, Chulho论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USACollis, Leon P.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USACrouse, Kimberly论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAFarnegardh, Mathias论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAFennell, Kimberly F.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAFish, Susan论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAFlick, Andrew C.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAGoos-Nilsson, Annika论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAGullberg, Hjalmar论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAHarris, Peter K.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAHeasley, Steven E.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAHegen, Martin论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAHromockyj, Alexander E.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAHu, Xiao论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAHusman, Bolette论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAJanosik, Tomasz论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAJones, Peter论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAKaila, Neelu论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAKallin, Elisabet论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAKauppi, Bjorn论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAKiefer, James R.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Worldwide Med Chem, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAKnafels, John论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAKoehler, Konrad论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAKruger, Lars论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USAKurumbail, Ravi G.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAKyne, Robert E., Jr.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USALi, Wei论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USALofstedt, Joakim论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USALong, Scott A.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Worldwide Med Chem, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAMenard, Carol A.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAMente, Scot论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Cambridge, MA 02139 USAMessing, Dean论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Cambridge, MA 02139 USAMeyers, Marvin J.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Worldwide Med Chem, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USANapierata, Lee论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, Cambridge, MA 02139 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USANoteberg, Daniel论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USANuhant, Philippe论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Med Design, Groton, CT 06340 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAPelc, Matthew J.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Worldwide Med Chem, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USAPrinsen, Michael J.论文数: 0 引用数: 0 h-index: 0机构: Pfizer Inc, Inflammat & Immunol Res, St Louis, MO 63017 USA Pfizer Inc, Med Design, Cambridge, MA 02139 USARhonnstad, Patrik论文数: 0 引用数: 0 h-index: 0机构: Karo Pharma AB, S-11148 Stockholm, Sweden Pfizer Inc, Med Design, Cambridge, MA 02139 USA
- [42] NATURAL PRODUCT CHEMISTRY .168. ONE-POT SYNTHESIS OF 3-[2-(5,7,9-TRIMETHOXY-2,2-DIMETHYL-2H-PYRANO[2,3-B]QUINOLIN-4-YL)-3-HYDROXY-3-METHYL]BUTYL-4,6,8-TRIMETHOXY-1H-QUINOLIN-2-ONEMONATSHEFTE FUR CHEMIE, 1993, 124 (11-12): : 1221 - 1224REISCH, J论文数: 0 引用数: 0 h-index: 0NORDHAUS, P论文数: 0 引用数: 0 h-index: 0
- [43] Discovery of N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of ObesityJOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (10) : 4028 - 4037Yan, Lin论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAHuo, Pei论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USADebenham, John S.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAMadsen-Duggan, Christina B.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USALao, Julie论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAChen, Richard Z.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAXiao, Jing Chen论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAShen, Chun-Pyn论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAStribling, D. Sloan论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Pharmacol, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAShearman, Lauren P.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Pharmacol, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAStrack, Alison M.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Pharmacol, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USATsou, Nancy论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Pharmaceut Res & Dev, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USABall, Richard G.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Pharmaceut Res & Dev, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAWang, Junying论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Drug Metab & Pharmacokinet, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USATong, Xinchun论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Drug Metab & Pharmacokinet, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USABateman, Thomas J.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Drug Metab & Pharmacokinet, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAReddy, Vijay B. G.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Drug Metab & Pharmacokinet, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAFong, Tung M.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USAHale, Jeffrey J.论文数: 0 引用数: 0 h-index: 0机构: Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA
- [44] Optimization of Activity, Selectivity, and Liability Profiles in 5-0xopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichloropheny1)-2-methyl5-oxo-5H-pyrrolo(3,4-b)pyridin-6(7H)-y1)-N,N-dimethylacetamide (BMS-767778)JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (18) : 7343 - 7357Devasthale, Pratik论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAWang, Ying论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAWang, Wei论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAFevig, John论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAFeng, JianXin论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAWang, Aiying论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Biol, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAHarrity, Tom论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Biol, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAEgan, Don论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Biol, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAMorgan, Nathan论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Biol, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USACap, Michael论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Biol, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAFura, Aberra论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Pharmaceut Candidate Optimizat, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAKlei, Herbert E.论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Prot Sci & Struct, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAKish, Kevin论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Prot Sci & Struct, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAWeigelt, Carolyn论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Comp Assisted Drug Design, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USASun, Lucy论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Pharmaceut Candidate Optimizat, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USALevesque, Paul论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Pharmaceut Candidate Optimizat, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAMoulin, Frederic论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Pharmaceut Candidate Optimizat, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USALi, Yi-Xin论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Pharmaceut Candidate Optimizat, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAZahler, Robert论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAKirby, Mark S.论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Biol, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USAHamann, Lawrence G.论文数: 0 引用数: 0 h-index: 0机构: Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA Bristol Myers Squibb Res & Dev, Metab Dis Chem, Princeton, NJ 08543 USA