ANTIPROLIFERATIVE EFFECT OF COMBINED TUMOR-NECROSIS-FACTOR-ALPHA AND INTERFERON-ALPHA ON HUMAN PANCREATIC-CANCER IN-VITRO AND IN-VIVO

被引：0
|
作者：
WATANABE, T [1 ]
FUCHIMOTO, S [1 ]
IWAGAKI, H [1 ]
NONAKA, Y [1 ]
NEZU, M [1 ]
NISHINA, T [1 ]
MARUTAKA, M [1 ]
SUSAKI, K [1 ]
NAOMOTO, Y [1 ]
SHIIKI, S [1 ]
MATSUBARA, N [1 ]
ORITA, K [1 ]
机构：
[1] OKAYAMA UNIV,SCH MED,DEPT SURG 1,2-5-1 SHIKATA CHO,OKAYAMA 700,JAPAN
来源：
ANTICANCER RESEARCH | 1993年 / 13卷 / 5A期
关键词：
TUMOR NECROSIS FACTOR-ALPHA; INTERFERON-ALPHA; HUMAN PANCREATIC TUMORS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The anti-proliferative effects of tumour necrosis factor-alpha (TNF-alpha) and interferon-alpha (IFN-alpha), alone or in combination, on human pancreatic cancer cells lines (PANC-1, ML4 PaCa-2 and BxPC-3) and human pancreatic cancer tumour (Exp-58), were investigated in vitro and in vivo. The anti-proliferative effect was determined using the dye uptake method and the subcutaneous tumour model. Combined TNF-alpha and IFN-alpha demonstrated marked synergistic and/or additive effects in comparison with their effects as single agents. These results suggest that combined-cytokine therapy of TNF-alpha and IFN-alpha may make possible some improvement in the treatment of pancreatic carcinoma patients in the future.
引用
收藏
页码：1501 / 1506
页数：6
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