ANTIPROLIFERATIVE EFFECT OF COMBINED TUMOR-NECROSIS-FACTOR-ALPHA AND INTERFERON-ALPHA ON HUMAN PANCREATIC-CANCER IN-VITRO AND IN-VIVO

被引：0

作者：

WATANABE, T ^{[1
]}

FUCHIMOTO, S ^{[1
]}

IWAGAKI, H ^{[1
]}

NONAKA, Y ^{[1
]}

NEZU, M ^{[1
]}

NISHINA, T ^{[1
]}

MARUTAKA, M ^{[1
]}

SUSAKI, K ^{[1
]}

NAOMOTO, Y ^{[1
]}

SHIIKI, S ^{[1
]}

MATSUBARA, N ^{[1
]}

ORITA, K ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT SURG 1,2-5-1 SHIKATA CHO,OKAYAMA 700,JAPAN

来源：

ANTICANCER RESEARCH | 1993年 / 13卷 / 5A期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; INTERFERON-ALPHA; HUMAN PANCREATIC TUMORS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The anti-proliferative effects of tumour necrosis factor-alpha (TNF-alpha) and interferon-alpha (IFN-alpha), alone or in combination, on human pancreatic cancer cells lines (PANC-1, ML4 PaCa-2 and BxPC-3) and human pancreatic cancer tumour (Exp-58), were investigated in vitro and in vivo. The anti-proliferative effect was determined using the dye uptake method and the subcutaneous tumour model. Combined TNF-alpha and IFN-alpha demonstrated marked synergistic and/or additive effects in comparison with their effects as single agents. These results suggest that combined-cytokine therapy of TNF-alpha and IFN-alpha may make possible some improvement in the treatment of pancreatic carcinoma patients in the future.

引用

页码：1501 / 1506

页数：6

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