NEW 1,2,6-THIADIAZINE DIOXIDE ACYCLONUCLEOSIDES - SYNTHESIS AND ANTIVIRAL EVALUATION

被引：14
|
作者：
ESTEBAN, AI
JUANES, O
CONDE, S
GOYA, P
DECLERCQ, E
MARTINEZ, A
机构：
[1] CSIC, INST QUIM MED, E-28006 MADRID, SPAIN
[2] KATHOLIEKE UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 11期
关键词：
D O I：
10.1016/0968-0896(95)00140-C
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New acyclonucleosides derived from 1,2,6-thiadiazine dioxide systems have been synthesized. Lipase-mediated deacylation procedure was used to obtain the deprotected derivatives. All the newly prepared compounds were tested as antiviral agents, but none of them showed significant activity.
引用
收藏
页码：1527 / 1535
页数：9
相关论文
共 50 条
  • [21] AMINO-GROUP EXCHANGE AND RING-CLEAVAGE REACTIONS IN FUSED 1,2,6-THIADIAZINE DIOXIDE DERIVATIVES
    FERNANDEZRESA, P
    GOYA, P
    NIEVES, R
    OCHOA, C
    STUD, M
    HETEROCYCLES, 1983, 20 (12) : 2351 - 2353
  • [22] A novel tetracyclic system containing the 1,2,6-thiadiazine ring: Synthesis, structural assignment and tautomeric studies
    Campillo, N
    de la Cruz, A
    Goya, P
    Paez, JA
    HETEROCYCLES, 1998, 48 (09) : 1833 - 1840
  • [23] SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES OF 1,2,6-THIADIAZINE 1,1-DIOXIDES - A COMPARATIVE-STUDY WITH PYRAZOLES
    ELGUERO, J
    OCHOA, C
    STUD, M
    ESTEBANCALDERON, C
    MARTINEZRIPOLL, M
    FAYET, JP
    VERTUT, MC
    JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (03): : 536 - 544
  • [24] SYNTHESIS AND E/Z STEREOISOMERISM OF 6-CARBALDOXIME DERIVATIVES OF PYRAZINO[2,3-C]-1,2,6-THIADIAZINE 2,2-DIOXIDE
    ALKORTA, I
    GOYA, P
    PAEZ, JA
    HETEROCYCLES, 1991, 32 (02) : 279 - 284
  • [25] RING TRANSFORMATION OF 1,2,6-THIADIAZINE 1,1-DIOXIDES INTO PYRAZOLES - A CONVENIENT SYNTHESIS OF N-ALKYLSULFAMIDES
    ELGUERO, J
    GOYA, P
    MARTINEZ, A
    HETEROCYCLES, 1989, 29 (02) : 245 - 248
  • [26] ORGANOMETALLICS IN CARBON CARBON BOND FORMATION IN 1,2,6-THIADIAZINE 1,1-DIOXIDES
    WANG, LRR
    BENNECHE, T
    UNDHEIM, K
    ACTA CHEMICA SCANDINAVICA, 1990, 44 (07): : 726 - 732
  • [27] Synthesis of trifluoromethyl-substituted 1,2,6-thiadiazine 1-oxides from sulfonimidamides under mechanochemical conditions
    Passia, Marco Thomas
    Schoebel, Jan-Hendrik
    Lentelink, Niklas Julian
    Truong, Khai-Nghi
    Rissanen, Kari
    Bolm, Carsten
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 19 (43) : 9470 - 9475
  • [28] STUDY OF THE REACTIVITY OF 3-OXO-1,2,6-THIADIAZINE 1,1-DIOXIDES
    GOYA, P
    MOLINA, C
    OCHOA, C
    STUD, M
    HETEROCYCLES, 1981, 16 (01) : 5 - 7
  • [29] GLYCOSIDES OF PYRIDO[2,3-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES
    DELACRUZ, A
    GOYA, P
    MARTINEZ, A
    PAEZ, JA
    NUCLEOSIDES & NUCLEOTIDES, 1990, 9 (01): : 69 - 79
  • [30] DISORDER PROBLEM - 3,5-DIAMINO-4-HYDROXYIMINO-4H-1,2,6-THIADIAZINE 1,1-DIOXIDE
    FOCESFOCES, C
    FAYOS, J
    CANO, FH
    GARCIABLANCO, S
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1977, 33 (MAR15): : 910 - 913
12345