NEW 1,2,6-THIADIAZINE DIOXIDE ACYCLONUCLEOSIDES - SYNTHESIS AND ANTIVIRAL EVALUATION

被引：14
|
作者：
ESTEBAN, AI
JUANES, O
CONDE, S
GOYA, P
DECLERCQ, E
MARTINEZ, A
机构：
[1] CSIC, INST QUIM MED, E-28006 MADRID, SPAIN
[2] KATHOLIEKE UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 11期
关键词：
D O I：
10.1016/0968-0896(95)00140-C
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New acyclonucleosides derived from 1,2,6-thiadiazine dioxide systems have been synthesized. Lipase-mediated deacylation procedure was used to obtain the deprotected derivatives. All the newly prepared compounds were tested as antiviral agents, but none of them showed significant activity.
引用
收藏
页码：1527 / 1535
页数：9
相关论文
共 50 条
  • [1] Synthesis and antiviral activity of modified 1,2,6-thiadiazine dioxide acyclonucleosides
    Esteban, AI
    DeClercq, E
    Martinez, A
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1997, 16 (03): : 265 - 276
  • [2] SYNTHESIS AND ANTIPROTOZOAL PROPERTIES OF 1,2,6-THIADIAZINE 1,1-DIOXIDE DERIVATIVES
    HERRERO, A
    OCHOA, C
    ATIENZA, J
    ESCARIO, JA
    GOMEZBARRIO, A
    FERNANDEZ, ARM
    ARCHIV DER PHARMAZIE, 1992, 325 (08) : 509 - 514
  • [3] SYNTHESIS OF 1,2,6-THIADIAZINE 1,1-DIOXIDES VIA ISOXAZOLYLSULFAMIDES
    ALBRECHT, HA
    BLOUNT, JF
    KONZELMANN, FM
    PLATI, JT
    JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (23): : 4191 - 4194
  • [4] SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1H-1,2,6-THIADIAZINE 1,1-DIOXIDE AND 1H,7H-IMIDAZO(4,5-E) (1,2,6)THIADIAZINE 2,2-DIOXIDE DERIVATIVES
    BREINING, T
    CIMPOIA, AR
    MANSOUR, TS
    HOPEWELL, P
    ASHMAN, C
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 27 - MEDI
  • [5] REGIOSELECTIVE N-ALKYLATION OF 1,2,6-THIADIAZINE 1,1-DIOXIDE DERIVATIVES
    GOYA, P
    MARTINEZ, P
    OCHOA, C
    STUD, M
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1981, 18 (03) : 459 - 462
  • [6] ALKYLATION OF 1,2,6-THIADIAZINE 1,1-DIOXIDES
    ROE, AM
    HARBRIDG.JB
    CHEMISTRY & INDUSTRY, 1965, (04) : 182 - +
  • [7] STRUCTURE OF 1,2,6-THIADIAZINE 1,1-DIOXIDES
    ELGUERO, J
    GOYA, P
    MARTINEZ, A
    ROZAS, I
    MO, O
    DEPAZ, JLG
    YANEZ, M
    JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 1990, 3 (07) : 470 - 476
  • [8] 3,5-DIAMINO-1,2,6-THIADIAZINE 1,1-DIOXIDE DERIVATIVES - SYNTHESIS AND ANTIPARASITIC ACTIVITY
    ARAN, VJ
    BIELSA, AG
    GOYA, P
    OCHOA, C
    PAEZ, JA
    TUD, M
    CONTRERAS, M
    ESCARIO, JA
    JIMENEZ, MI
    DURAN, EA
    DELACUESTA, CP
    FARMACO-EDIZIONE SCIENTIFICA, 1986, 41 (11): : 862 - 872
  • [9] SYNTHESIS AND SPECTROSCOPIC STUDY OF A NOVEL TRICYCLIC SYSTEM CONTAINING THE 1,2,6-THIADIAZINE 1,1-DIOXIDE MOIETY
    HERRERO, A
    OCHOA, C
    JIMENO, L
    SAMAT, A
    TETRAHEDRON, 1990, 46 (05) : 1679 - 1686
  • [10] ACENAPHTHO[5,6-CD]1,2,6-THIADIAZINE
    FLOWERDAY, P
    PERKINS, MJ
    TETRAHEDRON LETTERS, 1968, (10) : 1261 - +
12345