Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease

被引:10
|
作者
Yi, Geum-Chae-Won [1 ]
Yoon, Ka-Hyun [1 ]
Hwang, Jin-Bok [1 ]
机构
[1] Keimyung Univ, Dept Pediat, Sch Med, Daegu, South Korea
关键词
Crohn disease; Inflammatory bowel diseases; Acute pancreatitis; Azathioprine; 6-mercaptopurine; Mesalamine; Child;
D O I
10.5223/pghn.2012.15.4.272
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn disease was admitted due to high fever and severe epigastric pain during administration of mesalazine and azathioprine. Blood test and abdominal ultrasonography revealed acute pancreatitis. After discontinuance of the medication and supportive care, the symptoms and laboratory findings improved. A single, low dose challenge test was done to confirm the relationship of the adverse drug reaction and acute pancreatitis, and to discriminate the responsible drug. Azathioprine and 6-mercaptopurine showed positive responses, and mesalazine showed a negative response. We introduce the method of single, low dose challenge test and its interpretation for drug-induced pancreatitis.
引用
收藏
页码:272 / 275
页数:4
相关论文
共 50 条
  • [41] Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury
    Tapner, MJ
    Jones, BE
    Wu, WM
    Farrell, GC
    JOURNAL OF HEPATOLOGY, 2004, 40 (03) : 454 - 463
  • [42] The Role of Methotrexate in Azathioprine and 6-Mercaptopurine-induced Pancreatitis in Inflammatory Bowel Disease Patients
    Patel, Nisha
    Weatherly, Julie
    Abraham, Bincy
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2013, 108 : S555 - S555
  • [43] The use of G-CSF for 6-mercaptopurine induced leukopenia in a patient with Crohn's disease
    Huang, CS
    Sentovich, S
    Farraye, FA
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2002, 97 (09): : S189 - S190
  • [44] Successful Use of N-Acetylcysteine for 6-Mercaptopurine Induced Hepatotoxity in Crohn's Disease
    Kaur, Antarpreet
    Rustagi, Tarun
    Ibrahim, Danyal
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2010, 105 : S304 - S305
  • [45] Azathioprine/6-mercaptopurine (AZA/6-MP) reduces the risk of intestinal re-operation in Crohn's Disease(CD)
    Papay, Pavol
    Ho, Elien
    Reinisch, Walter
    Miehsler, Wolfgang
    Vogelsang, Harald
    Novacek, Gottfried
    GASTROENTEROLOGY, 2007, 132 (04) : A52 - A52
  • [46] Case Report: Acute Myeloblastic Leukemia Following Prolonged Treatment of Crohn's Disease with 6-Mercaptopurine
    William D. Heizer
    John L. Peterson
    Digestive Diseases and Sciences, 1998, 43 : 1791 - 1793
  • [47] LOW-DOSE 6-MERCAPTOPURINE IN INFLAMMATORY DOWEL DISEASE IS ASSOCIATED WITH MINIMAL HEMATOLOGIC TOXICITY
    BERNSTEIN, CN
    ARTINIAN, L
    ANTON, PA
    SHANAHAN, F
    DIGESTIVE DISEASES AND SCIENCES, 1994, 39 (08) : 1638 - 1641
  • [48] SUBCUTANEOUS FAT NECROSIS WITH ACUTE HEMORRHAGIC PANCREATITIS - A CASE IN A CHILD WITH STEROID-RESISTANT NEPHROSIS TREATED WITH 6-MERCAPTOPURINE
    HEUSER, E
    LIEBERMAN, E
    DONNELL, GN
    LANDING, BH
    CALIFORNIA MEDICINE, 1967, 106 (01): : 58 - +
  • [49] The effects of azathioprine/6-mercaptopurine and TNF-alpha antagonist on surgery in Korean patients with Crohn's disease from the CONNECT cohort
    Kim, H. M.
    Kim, H. -S.
    Kim, J. H.
    Kim, H. S.
    Lee, K. J.
    Park, H. J.
    Kim, J. W.
    Kim, J. S.
    Kim, Y. S.
    Cheon, J. H.
    Ye, B. D.
    Kim, Y. H.
    Han, D. S.
    JOURNAL OF CROHNS & COLITIS, 2015, 9 : S415 - S415
  • [50] Azathioprine and 6-Mercaptopurine for the Prevention of Postoperative Recurrence in Crohn's Disease : A Meta-Analysis of Controlled Trials with Individual Patient Data
    Peyrin-Biroulet, Laurent
    Deltenre, Pierre
    Ardizzone, Sandro
    D'Haens, Geert R.
    Hanauer, Stephen B.
    Herfarth, Hans H.
    Lemann, Marc
    Colombel, Jean-Frederic
    GASTROENTEROLOGY, 2009, 136 (05) : A522 - A522