Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease

被引:10
|
作者
Yi, Geum-Chae-Won [1 ]
Yoon, Ka-Hyun [1 ]
Hwang, Jin-Bok [1 ]
机构
[1] Keimyung Univ, Dept Pediat, Sch Med, Daegu, South Korea
关键词
Crohn disease; Inflammatory bowel diseases; Acute pancreatitis; Azathioprine; 6-mercaptopurine; Mesalamine; Child;
D O I
10.5223/pghn.2012.15.4.272
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn disease was admitted due to high fever and severe epigastric pain during administration of mesalazine and azathioprine. Blood test and abdominal ultrasonography revealed acute pancreatitis. After discontinuance of the medication and supportive care, the symptoms and laboratory findings improved. A single, low dose challenge test was done to confirm the relationship of the adverse drug reaction and acute pancreatitis, and to discriminate the responsible drug. Azathioprine and 6-mercaptopurine showed positive responses, and mesalazine showed a negative response. We introduce the method of single, low dose challenge test and its interpretation for drug-induced pancreatitis.
引用
收藏
页码:272 / 275
页数:4
相关论文
共 50 条
  • [21] Use of 6-mercaptopurine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease - Balance
    Jacobstein, DA
    Baldassano, RN
    INFLAMMATORY BOWEL DISEASES, 2005, 11 (02) : 203 - 205
  • [22] Efficacy of mycophenolate mofetil in patients failing 6-mercaptopurine or azathioprine therapy for Crohn's disease
    Hassard, PV
    Vasiliauskas, EA
    Kam, LY
    Targan, SR
    Abreu, MT
    INFLAMMATORY BOWEL DISEASES, 2000, 6 (01) : 16 - 20
  • [23] 6-mercaptopurine pharmacokinetics and blood lymphocyte subpopulations in patients with Crohn's disease treated with azathioprine
    Cattan, S
    Lemann, M
    Thuillier, F
    Bengoufa, D
    Rabian, C
    Ngo, Y
    Bouhnik, Y
    Messing, B
    Rambaud, JC
    Modigliani, R
    GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 1998, 22 (02): : 160 - 167
  • [24] Use of 6-mercaptopurine/azathioprine as the immunornodulator of choice for moderately active Crohn's disease - Pro
    Hyams, JS
    INFLAMMATORY BOWEL DISEASES, 2005, 11 (02) : 197 - 199
  • [25] Azathioprine and 6-Mercaptopurine for the Prevention of Postoperative Recurrence in Crohn's Disease: A Meta-Analysis
    Peyrin-Biroulet, Laurent
    Deltenre, Pierre
    Ardizzone, Sandro
    D'Haens, Geert
    Hanauer, Stephen B.
    Herfarth, Hans
    Lemann, Marc
    Colombel, Jean-Frederic
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 (08): : 2089 - 2096
  • [26] AZATHIOPRINE/6-MERCAPTOPURINE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) - A SINGLE CENTRE EXPERIENCE
    Costantino, G.
    Sergi, M. D.
    Lo Presti, M. A.
    Della Torre, A.
    Corrente, E.
    Ocera, L.
    Di Benedetto, A.
    Romano, C.
    Fries, W.
    DIGESTIVE AND LIVER DISEASE, 2008, 40 : S134 - S135
  • [27] Treatment of Crohn's disease (CD) with 6-mercaptopurine (6-MP) in patients intolerant to azathioprine (AZA).
    Lemann, M
    Bouhnik, Y
    Corguille, MKL
    Bonnet, J
    Coffin, B
    Marteau, P
    Bitoun, A
    Messing, B
    Jian, R
    Matuchansky, C
    Modigliani, R
    Rambaud, JC
    GASTROENTEROLOGY, 1997, 112 (04) : A1025 - A1025
  • [28] Extremely low dose of 6-mercaptopurine in a Chinese child with acute lymphoblastic leukaemia and multiple pharmacogenetic mutations
    Zhai, Xiao-Ying
    Zhou, Yue
    Dong, Lei
    Nie, Ai-Qing
    Zhi, Li-Juan
    Jacqz-Aigrain, Evelyne
    Wang, Tian-You
    Wang, Li
    Zhao, Wei
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2021, 46 (01) : 74 - 77
  • [29] Azathioprine or mercaptopurine-induced acute pancreatitis is not a disease-specific phenomenon
    Van Geenen, E. J. M.
    De Boer, N. K. H.
    Stassen, P.
    Linskens, R. K.
    Bruno, M. J.
    Mulder, C. J. J.
    Stegeman, C. A.
    Van Bodegraven, A. A.
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2010, 31 (12) : 1322 - 1329
  • [30] The efficacy of azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in patients with Crohn's disease remains uncertain
    Sandborn, WJ
    Feagan, BG
    GASTROENTEROLOGY, 2004, 127 (03) : 990 - 993