In congestive heart failure, increased secretion of atrial natriuretic peptide (ANP) is an important compensatory mechanism that unloads the failing heart and promotes renal salt and water excretion. However, activation of opposing sodium-retaining factors, particularly the renin-angiotensin system, reduces renal responsiveness to ANP and shifts the cardiovascular system to a state of decompensation.
机构:
Univ Auckland, Dept Gen Practice & Primary Hlth Care, Auckland 1142, New ZealandUniv Auckland, Dept Gen Practice & Primary Hlth Care, Auckland 1142, New Zealand