In congestive heart failure, increased secretion of atrial natriuretic peptide (ANP) is an important compensatory mechanism that unloads the failing heart and promotes renal salt and water excretion. However, activation of opposing sodium-retaining factors, particularly the renin-angiotensin system, reduces renal responsiveness to ANP and shifts the cardiovascular system to a state of decompensation.
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Univ Calif Davis, Dept Internal Med, 4860 Y St Suite 0100, Sacramento, CA 95817 USAUniv Calif Davis, Dept Internal Med, 4860 Y St Suite 0100, Sacramento, CA 95817 USA
Chen, Jennifer
Aronowitz, Paul
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Univ Calif Davis, Dept Internal Med, 4150 V Street Suite 3100 PSSB, Sacramento, CA 95817 USAUniv Calif Davis, Dept Internal Med, 4860 Y St Suite 0100, Sacramento, CA 95817 USA
机构:
Univ Maryland, Med Ctr, Dept Emergency Med, Emergency Med Internal Med Crit Care Program, Baltimore, MD 21201 USA
Univ Maryland, Med Ctr, Dept Med, Baltimore, MD 21201 USAUniv Maryland, Med Ctr, Dept Emergency Med, Emergency Med Internal Med Crit Care Program, Baltimore, MD 21201 USA
Scott, Michael C.
Winters, Michael E.
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Univ Maryland, Med Ctr, Dept Emergency Med, Emergency Med Internal Med Crit Care Program, Baltimore, MD 21201 USAUniv Maryland, Med Ctr, Dept Emergency Med, Emergency Med Internal Med Crit Care Program, Baltimore, MD 21201 USA