THEORETICAL PREDICTION OF SECONDARY STRUCTURES OF PROTEINS USING RECOGNITION FACTORS

被引:0
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作者
THORNTON, S
FABIAN, ES
FRAGA, S
PARKER, JMR
HODGES, RS
机构
[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA
[2] UNIV ALBERTA,DEPT BIOCHEM,EDMONTON T6G 2H7,ALBERTA,CANADA
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中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A knowledge of the secondary structure of a protein will aid in improving the theoretical prediction of its tertiary structure, at a considerably reduced cost in terms of computing time. It is shown in this work that the fragments of a protein may be predicted from the information contained in the recognition and flexibility profiles, constructed from the corresponding factors. The accuracy of the predictions for 88 proteins highlights the significance of the recognition factors of theoretical origin developed at this laboratory.
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页码:87 / 97
页数:11
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