THE CONTROL OF INTERFERON-INDUCIBLE GENE-EXPRESSION

被引：66
|
作者：
KERR, IM
STARK, GR
机构：
来源：
FEBS LETTERS | 1991年 / 285卷 / 02期
关键词：
GENE EXPRESSION; INTERFERON-INDUCIBLE; MUTANT; VIRAL INHIBITION;
D O I：
10.1016/0014-5793(91)80802-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The alpha-beta-interferons (IFNs) transiently induce genes through the IFN-stimulable DNA response element (ISRE). IFN-cell surface receptor interaction triggers the cytoplasmic activation of the complex primary transcription factor E, which on translocation and interaction with the ISRE initiates transcription. Whether E is activated directly through the receptor(s) or through a more classical second message pathway(s) and the roles of additional factors in the alpha-beta and gamma-IFN responses remain to be established. Meanwhile analysis of mutants has revealed complexity and overlap in the alpha-beta and gamma-IFN response pathways and the products of at least two viruses have been shown to inhibit IFN-inducible gene expression.
引用
收藏
页码：194 / 198
页数：5
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