THE CONTROL OF INTERFERON-INDUCIBLE GENE-EXPRESSION

被引：66
|
作者：
KERR, IM
STARK, GR
机构：
来源：
FEBS LETTERS | 1991年 / 285卷 / 02期
关键词：
GENE EXPRESSION; INTERFERON-INDUCIBLE; MUTANT; VIRAL INHIBITION;
D O I：
10.1016/0014-5793(91)80802-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The alpha-beta-interferons (IFNs) transiently induce genes through the IFN-stimulable DNA response element (ISRE). IFN-cell surface receptor interaction triggers the cytoplasmic activation of the complex primary transcription factor E, which on translocation and interaction with the ISRE initiates transcription. Whether E is activated directly through the receptor(s) or through a more classical second message pathway(s) and the roles of additional factors in the alpha-beta and gamma-IFN responses remain to be established. Meanwhile analysis of mutants has revealed complexity and overlap in the alpha-beta and gamma-IFN response pathways and the products of at least two viruses have been shown to inhibit IFN-inducible gene expression.
引用
收藏
页码：194 / 198
页数：5
相关论文
共 50 条
  • [31] Interferon-inducible gene expression signature in peripheral blood cells of patients with severe SLE.
    Baechler, EC
    Batliwala, FM
    Karypis, G
    Gaffney, PM
    Ortmann, WA
    Espe, KJ
    Shark, KB
    Grande, WJ
    Hughes, KM
    Kapur, V
    Gregersen, PK
    Behrens, TW
    ARTHRITIS AND RHEUMATISM, 2002, 46 (09): : S281 - S281
  • [32] Interferon-inducible gene expression is characteristic of ectopic lymphoid tissue in pristane-induced lupus
    Nacionales, DC
    Yan, XJ
    Albesian, E
    Kelly, K
    Kuroda, Y
    Akaogi, J
    Satoh, M
    Nicholas, CI
    Reeves, WH
    ARTHRITIS AND RHEUMATISM, 2003, 48 (09): : S62 - S62
  • [33] Interferon-inducible Mx gene expression in cotton rats: Cloning, characterization, and expression during influenza viral infection
    Pletneva, Lioubov M.
    Haller, Otto
    Porter, David D.
    Prince, Gregory A.
    Blanco, Jorge C. G.
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2006, 26 (12): : 914 - 921
  • [34] HUMAN BETA-INTERFERON GENE-EXPRESSION IS REGULATED BY AN INDUCIBLE ENHANCER ELEMENT
    GOODBOURN, S
    ZINN, K
    MANIATIS, T
    CELL, 1985, 41 (02) : 509 - 520
  • [35] Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis
    Walsh, Ronan J.
    Kong, Sek Won
    Yao, Yihong
    Jallal, Bahija
    Kiener, Peter A.
    Pinkus, Jack L.
    Beggs, Alan H.
    Amato, Anthony A.
    Greenberg, Steven A.
    ARTHRITIS AND RHEUMATISM, 2007, 56 (11): : 3784 - 3792
  • [36] PROMOTER REGION ANALYSIS OF AN INTERFERON-INDUCIBLE GENE ASSOCIATED WITH MACROPHAGE ACTIVATION
    NICOLET, CM
    PAULNOCK, DM
    JOURNAL OF IMMUNOLOGY, 1993, 150 (08): : A84 - A84
  • [37] Effect on interferon-inducible gene expression signature by ABR215757, a new drug in development for SLE
    Liberg, David
    Kallberg, Eva
    Olsson, Anders
    Bengtsson, Anders A.
    Ronnblom, Lars
    Leanderson, Tomas
    ARTHRITIS AND RHEUMATISM, 2008, 58 (09): : S567 - S568
  • [38] Expression of interferon-inducible genes is influenced by sex hormones and gender in SLE
    Hossain, Awlad
    Hahn, Bevra
    Singh, Ram
    JOURNAL OF IMMUNOLOGY, 2013, 190
  • [39] Interferon-inducible Mx proteins in fish
    Leong, JAC
    Trobridge, GD
    Kim, CHY
    Johnson, M
    Simon, B
    IMMUNOLOGICAL REVIEWS, 1998, 166 : 349 - 363
  • [40] Interferon-inducible genes and aplastic anemia
    Platanias, LC
    BLOOD, 2006, 107 (01) : 2 - 3
12345