NEURAL CELL-ADHESION MOLECULE (CD56)-POSITIVE, T(8-21) ACUTE MYELOID-LEUKEMIA (AML, M-2) AND GRANULOCYTIC SARCOMA

被引：35

作者：

KRISHNAN, K

ROSS, CW

ADAMS, PT

PEREIRA, A

ROTH, MS

机构：

[1] Division of Hematology-Oncology, Department of Internal Medicine, Upjohn Center, Ann Arbor, 48109-0504, MI, 1310, E. Catherine Drive

来源：

ANNALS OF HEMATOLOGY | 1994年 / 69卷 / 06期

关键词：

T(8-21) AML; GRANULOCYTIC SARCOMA; CD56; ADHESION MOLECULE;

D O I：

10.1007/BF01696563

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 49-year-old man with t(8; 21) acute myeloid leukemia relapsed 8 months after successful induction chemotherapy with a paraspinal granulocytic sarcoma. There was no evidence of leukemia in the bone marrow at relapse. At initial presentation, the blasts co-expressed CD 15, CD 33, CD 34, CD 45, CD 19, and CD 56 (a neural cell-adhesion molecule). Expression of certain cell-adhesion molecules on leukemic blasts may determine a tendency to develop extramedullary relapse. The co-expression of CD 56 may have a role in the predisposition of t(8; 21) AML to develop GS.

引用

页码：321 / 323

页数：3

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