NEURAL CELL-ADHESION MOLECULE (CD56)-POSITIVE, T(8-21) ACUTE MYELOID-LEUKEMIA (AML, M-2) AND GRANULOCYTIC SARCOMA

被引：35
|
作者：
KRISHNAN, K
ROSS, CW
ADAMS, PT
PEREIRA, A
ROTH, MS
机构：
[1] Division of Hematology-Oncology, Department of Internal Medicine, Upjohn Center, Ann Arbor, 48109-0504, MI, 1310, E. Catherine Drive
来源：
ANNALS OF HEMATOLOGY | 1994年 / 69卷 / 06期
关键词：
T(8-21) AML; GRANULOCYTIC SARCOMA; CD56; ADHESION MOLECULE;
D O I：
10.1007/BF01696563
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 49-year-old man with t(8; 21) acute myeloid leukemia relapsed 8 months after successful induction chemotherapy with a paraspinal granulocytic sarcoma. There was no evidence of leukemia in the bone marrow at relapse. At initial presentation, the blasts co-expressed CD 15, CD 33, CD 34, CD 45, CD 19, and CD 56 (a neural cell-adhesion molecule). Expression of certain cell-adhesion molecules on leukemic blasts may determine a tendency to develop extramedullary relapse. The co-expression of CD 56 may have a role in the predisposition of t(8; 21) AML to develop GS.
引用
收藏
页码：321 / 323
页数：3
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