The high-fat diet consisted of cholesterol, hydrogenated coconut oil, and cholic acid. In the blood serum and in liver homogenate lipid content, cholesterol, and triglycerides were assayed. Cytochrome P-450 concentration in liver microsomes was also estimated. In animals receiving selenium and vitamin E, the content of lipid fractions in the blood serum and liver homogenate fell, while the cytochrome P-450 content in the liver microsomes was markedly elevated. The intensified protective effect of vitamin E and selenium applied in combination against changes induced in the liver of animals receiving a HFD was confirmed by macroscopic and microscopic examination of the organ.
机构:
Univ Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USA
Univ Valencia, Dept Physiotherapy, Valencia, SpainUniv Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USA
Zarzoso, M.
Mironov, S.
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Univ Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USA
Mironov, S.
Guerrero-Serna, G.
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Univ Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USA
Guerrero-Serna, G.
Willis, B. Cicero
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Univ Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USA
Willis, B. Cicero
Pandit, S. V.
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Univ Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Arrhythmia Res, Ann Arbor, MI 48109 USA