GENOMIC ANALYSIS OF A MOUSE ZINC FINGER GENE, ZFP-35, THAT IS UP-REGULATED DURING SPERMATOGENESIS

被引：26
|
作者：
CUNLIFFE, V
WILLIAMS, S
TROWSDALE, J
机构：
[1] Imperial Cancer Research Fund Laboratories, London, WC2A 3PX
来源：
GENOMICS | 1990年 / 8卷 / 02期
关键词：
D O I：
10.1016/0888-7543(90)90290-B
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Zinc finger genes are a class of eukaryotic regulatory genes that encode sequence-specific nucleic acid-binding proteins. Members of this large gene family are required for growth and development in a wide range of organisms. We previously identified a mouse zinc finger gene, Zfp-35, that was up-regulated during spermatogenesis at the pachytene spermatocyte stage of development. We now describe the genomic organization of this gene, including its intron-exon structure, the sequence of its flanking regions, and its assignment to a region encompassing bands B3 to C of chromosome 18. The transcription unit has three exons. Intron 1 is within the 5′ untranslated region and exon 3 contains the block of all 18 zinc fingers. These two features are common to a number of zinc finger genes. We also show that Zfp-35 is conserved in some placental mammals and that it is a member of a subfamily of related mammalian zinc finger genes. © 1990.
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页码：331 / 339
页数：9
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