DIRECTING BROMINATION OF PIPERAZINE-2,5-DIONES

被引：17
|
作者：
BADRAN, TW
CHAI, CLL
EASTON, CJ
HARPER, JB
PAGE, DM
机构：
[1] UNIV ADELAIDE,DEPT CHEM,ADELAIDE,SA 5005,AUSTRALIA
[2] VICTORIA UNIV WELLINGTON,DEPT CHEM,WELLINGTON,NEW ZEALAND
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 1995年 / 48卷 / 07期
关键词：
D O I：
10.1071/CH9951379
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
From intermolecular and intramolecular competition experiments, it has been established that, by comparison with an N-methyl substituent, an N-acetyl group deactivates glycine residues in piperazine-2,5-diones towards free-radical bromination. Combined with the ease of introduction and removal of N-acetyl substituents, the deactivating effect provides a method for regiocontrolled functionalization of these compounds.
引用
收藏
页码：1379 / 1384
页数：6
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