Efficient organocatalytic α-sulfenylation of substituted piperazine-2,5-diones

被引：25

作者：

Dubey, Ramin ^{[1
]}

Polaske, Nathan W. ^{[1
]}

Nichol, Gary S. ^{[1
]}

Olenyuk, Bogdan ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 30期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CHAETOMIUM COCHLIODES; EPIPOLYTHIODIOXOPIPERAZINES; HYALODENDRIN; CHAETOCIN; ALDEHYDES;

D O I：

10.1016/j.tetlet.2009.05.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Organocatalytic alpha-sulfenylation of substituted piperazine-2,5-diones is reported through the use of cinchona alkaloids as Lewis bases and electrophilic sulfur transfer reagents. 1-Phenylsulfanyl[1,2,4]triazole, a novel Sulfur transfer reagent, gave excellent product yields with a number of substituted piperazine-2,5-diones under mild conditions. Catalyst loading, stoichiometry Of Sulfur electrophile, temperature, and solvent were optimized to achieve high product yields. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4310 / 4313

页数：4

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