KETOCONAZOLE AND HIGH-DOSE METHYLPREDNISOLONE PREDISPOSING TO CYCLOSPORINE-INDUCED SEIZURES - REPORT OF 3 CASES

被引：0
|
作者：
HWANG, WL [1 ]
GAU, JP [1 ]
YOUNG, JH [1 ]
CHIA, LG [1 ]
机构：
[1] TAICHUNG VET GEN HOSP,DEPT MED,DIV NEUROL,TAICHUNG,TAIWAN
来源：
ACTA HAEMATOLOGICA | 1992年 / 88卷 / 2-3期
关键词：
CYCLOSPORINE; GRAND MAL SEIZURE; KETOCONAZOLE; METHYLPREDNISOLONE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Three consecutive cases of severe aplastic anemia undergoing immunosuppressive therapy with cyclosporin A (CyA) and high-dose methylprednisolone (HDMP) developed grand mal seizures after receiving ketoconazole treatment. All the seizures were reversed after transient discontinuation of those drugs. To our knowledge, it has not been reported as yet that the combination of ketoconazole and HDMP may considerably increase the risk of CyA-induced seizure. We would advise that ketoconazole and HDMP not be taken concomitantly with CyA treatment, and whenever ketoconazole therapy is needed, CyA be started with as small a dose as possible.
引用
收藏
页码：139 / 141
页数：3
相关论文
共 50 条
  • [41] PROPHYLACTIC AND DELAYED TREATMENT WITH HIGH-DOSE METHYLPREDNISOLONE IN A PORCINE MODEL OF EARLY ARDS INDUCED BY ENDOTOXAEMIA
    BORG, T
    GERDIN, B
    MODIG, J
    ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1985, 29 (08) : 831 - 845
  • [42] High-dose methylprednisolone reduces cytokine-induced adhesion molecules on human brain endothelium
    Gelati, M
    Corsini, E
    Dufour, A
    Massa, G
    Giombini, S
    Solero, CL
    Salmaggi, A
    CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2000, 27 (03) : 241 - 244
  • [43] High-dose oral morphine in cancer pain management: A report of twelve cases
    Radbruch, L
    Grond, S
    Zech, DJ
    Bischoff, A
    JOURNAL OF CLINICAL ANESTHESIA, 1996, 8 (02) : 144 - 150
  • [44] High-Dose Thiamine Improves Fatigue After Stroke: A Report of Three Cases
    Costantini, Antonio
    Pala, Maria Immacolata
    Catalano, Maria Lucia
    Notarangelo, Cristiano
    Careddu, Pamela
    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2014, 20 (09) : 683 - 685
  • [45] The effect of high-dose methylprednisolone on laser-induced retinal injury in primates: an electron microscopic study
    Takahashi, K
    Lam, TT
    Fu, J
    Tso, MOM
    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1997, 235 (11) : 723 - 732
  • [46] The effect of high-dose methylprednisolone on laser-induced retinal injury in primates: an electron microscopic study
    Kanji Takahashi
    Tim T. Lam
    Jun Fu
    Mark O. M. Tso
    Graefe's Archive for Clinical and Experimental Ophthalmology, 1997, 235 : 723 - 732
  • [47] 4 CASES OF ACUTE CARDIAC DYSFUNCTION INDUCED BY HIGH-DOSE CYTARABINE CHEMOTHERAPY
    Kikukawa, Y.
    Watanabe, Y.
    Shimomura, T.
    Suzushima, H.
    ANNALS OF ONCOLOGY, 2012, 23 : 166 - 167
  • [48] High-Dose Steroid-Induced Protrusio Acetabuli: A Case Report
    Madenci, Ercan
    Egilmez, Zeliha
    Alkal, Semra
    Arslan, Pinar
    Mutlu, Hasan Huseyin
    TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS, 2015, 21 (01): : 34 - 36
  • [49] THYROID-CARCINOMA AFTER HIGH-DOSE EXTERNAL RADIOTHERAPY FOR HODGKINS-DISEASE - REPORT OF 3 CASES
    MCDOUGALL, IR
    COLEMAN, CN
    BURKE, JS
    SAUNDERS, W
    KAPLAN, HS
    CANCER, 1980, 45 (08) : 2056 - 2060
  • [50] Phase I trial of cyclosporine-induced autologous graft-versus-host disease in patients with multiple myeloma undergoing high-dose chemotherapy with autologous stem-cell rescue
    Giralt, S
    Weber, D
    Colome, M
    Dimopoulos, M
    Mehra, R
    VanBesien, K
    Gajewski, J
    Andersson, B
    Khouri, I
    Przepiorka, D
    vonWolff, B
    Delasalle, K
    Korbling, M
    Seong, D
    Alexanian, R
    Champlin, R
    JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) : 667 - 673
12345