KETOCONAZOLE AND HIGH-DOSE METHYLPREDNISOLONE PREDISPOSING TO CYCLOSPORINE-INDUCED SEIZURES - REPORT OF 3 CASES

被引：0
|
作者：
HWANG, WL [1 ]
GAU, JP [1 ]
YOUNG, JH [1 ]
CHIA, LG [1 ]
机构：
[1] TAICHUNG VET GEN HOSP,DEPT MED,DIV NEUROL,TAICHUNG,TAIWAN
来源：
ACTA HAEMATOLOGICA | 1992年 / 88卷 / 2-3期
关键词：
CYCLOSPORINE; GRAND MAL SEIZURE; KETOCONAZOLE; METHYLPREDNISOLONE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Three consecutive cases of severe aplastic anemia undergoing immunosuppressive therapy with cyclosporin A (CyA) and high-dose methylprednisolone (HDMP) developed grand mal seizures after receiving ketoconazole treatment. All the seizures were reversed after transient discontinuation of those drugs. To our knowledge, it has not been reported as yet that the combination of ketoconazole and HDMP may considerably increase the risk of CyA-induced seizure. We would advise that ketoconazole and HDMP not be taken concomitantly with CyA treatment, and whenever ketoconazole therapy is needed, CyA be started with as small a dose as possible.
引用
收藏
页码：139 / 141
页数：3
相关论文
共 50 条
  • [11] Very high-dose methylprednisolone for treatment of nivolumab-induced limbic encephalitis: A case report
    Taillefer, Vincent-Thierry
    Pigeon, Marjorie
    Chen, Michelle
    Larochelle, Catherine
    Florescu, Marie
    Belanger, Karl
    Adam, Jean-Philippe
    JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2020, 26 (06) : 1538 - 1543
  • [12] HIGH-DOSE METHYLPREDNISOLONE INHIBITS THE OKT3-INDUCED 1ST-DOSE REACTION
    PECES, R
    URRA, JM
    DELATORRE, M
    SANCHEZFRUCTUOSO, A
    LOPEZLARREA, C
    KIDNEY INTERNATIONAL, 1993, 44 (06) : 1485 - 1486
  • [13] Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
    Gutkowski, Krzysztof
    Chwist, Alina
    Hartleb, Marek
    HEPATITIS MONTHLY, 2011, 11 (08) : 656 - 661
  • [14] Presumptive iatrogenic hypoadrenocorticism induced by high-dose ketoconazole administration in a dog
    Hernandez-Bures, Andrea
    White, Amelia G.
    Riordan, Laura
    JOURNAL OF VETERINARY INTERNAL MEDICINE, 2019, 33 (05) : 2235 - 2238
  • [15] CYCLOSPORINE IN THE TREATMENT OF ACUTE CADAVERIC KIDNEY GRAFT-REJECTION REFRACTORY TO HIGH-DOSE METHYLPREDNISOLONE
    MARGREITER, R
    HUBER, C
    SPIELBERGER, M
    KONIG, P
    TRANSPLANTATION, 1983, 36 (02) : 203 - 204
  • [16] HIGH-DOSE METHYLPREDNISOLONE INHIBITS THE OKT3-INDUCED CYTOKINE-RELATED SYNDROME
    PECES, R
    URRA, JM
    ESCALADA, P
    GOROSTIDI, M
    GONZALEZ, E
    LOPEZLARREA, C
    NEPHRON, 1993, 63 (01): : 118 - 118
  • [17] INHIBITION BY CYCLOSPORINE OF EOSINOPHILIA INDUCED BY HIGH-DOSE CYCLOPHOSPHAMIDE PRIOR TO IMMUNIZATION
    THOMSON, AW
    MILTON, JI
    ALDRIDGE, RD
    SIMPSON, JG
    DAVIDSON, RJL
    TRANSPLANTATION PROCEEDINGS, 1986, 18 (04) : 895 - 897
  • [18] Granisetron plus methylprednisolone for the control of high-dose cisplatin-induced emesis
    Kleisbauer, JP
    Garcia-Giron, C
    Antimi, M
    Azevedo, MC
    Balmes, H
    Massuti-Sureda, B
    Contu, A
    Luque, A
    Pellier, P
    ANTI-CANCER DRUGS, 1998, 9 (05) : 387 - 392
  • [19] High-dose methylprednisolone-induced hepatitis in a patient with multiple sclerosis: A case report and brief review of literature
    D'Agnolo, H. M. A.
    Drenth, J. P. H.
    NETHERLANDS JOURNAL OF MEDICINE, 2013, 71 (04): : 199 - 202
  • [20] Experimental osteonecrosis induced by a combination of low-dose lipopolysaccharide and high-dose methylprednisolone in rabbits
    Wu, Xinghuo
    Yang, Shuhua
    Duan, Deyu
    Zhang, Yukun
    Wang, Jing
    JOINT BONE SPINE, 2008, 75 (05) : 573 - 578
12345