KETOCONAZOLE AND HIGH-DOSE METHYLPREDNISOLONE PREDISPOSING TO CYCLOSPORINE-INDUCED SEIZURES - REPORT OF 3 CASES

被引：0
|
作者：
HWANG, WL [1 ]
GAU, JP [1 ]
YOUNG, JH [1 ]
CHIA, LG [1 ]
机构：
[1] TAICHUNG VET GEN HOSP,DEPT MED,DIV NEUROL,TAICHUNG,TAIWAN
来源：
ACTA HAEMATOLOGICA | 1992年 / 88卷 / 2-3期
关键词：
CYCLOSPORINE; GRAND MAL SEIZURE; KETOCONAZOLE; METHYLPREDNISOLONE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Three consecutive cases of severe aplastic anemia undergoing immunosuppressive therapy with cyclosporin A (CyA) and high-dose methylprednisolone (HDMP) developed grand mal seizures after receiving ketoconazole treatment. All the seizures were reversed after transient discontinuation of those drugs. To our knowledge, it has not been reported as yet that the combination of ketoconazole and HDMP may considerably increase the risk of CyA-induced seizure. We would advise that ketoconazole and HDMP not be taken concomitantly with CyA treatment, and whenever ketoconazole therapy is needed, CyA be started with as small a dose as possible.
引用
收藏
页码：139 / 141
页数：3
相关论文
共 50 条
  • [1] SEIZURES AFTER ANTIEMETIC TREATMENT WITH HIGH-DOSE DOMPERIDONE - REPORT OF 4 CASES
    WEAVING, A
    BEZWODA, WR
    DERMAN, DP
    BRITISH MEDICAL JOURNAL, 1984, 288 (6432): : 1728 - 1728
  • [2] Enhanced Interaction betweenWarfarin and High-Dose Ketoconazole: A Case Report
    Jackevicius, Cynthia A.
    Ton, Mannhu N.
    CASE REPORTS IN MEDICINE, 2009, 2009
  • [3] EPILEPTIC SEIZURES INDUCED BY HIGH-DOSE BUSULFAN
    ALSAR, MJ
    SOTO, J
    SACRISTAN, JA
    RICHARD, C
    MEDICINA CLINICA, 1991, 96 (06): : 238 - 239
  • [4] OKT3-INDUCED CYTOKINE RELEASE ATTENUATION BY HIGH-DOSE METHYLPREDNISOLONE
    GOLDMAN, M
    ABRAMOWICZ, D
    DEPAUW, L
    ALEGRE, ML
    WIDERA, I
    VEREERSTRAETEN, P
    KINNAERT, P
    LANCET, 1989, 2 (8666): : 802 - 803
  • [5] Corticosteroid-induced bradycardia following high-dose methylprednisolone administration: a case report
    Zkib, Jwil
    Sattout, Raneem
    Faour, Sabah
    Haddad, Sultaneh
    Bassut, Ranim
    Swed, Wajd
    Hritani, Shahd
    Mansouer, Milad
    Ghabally, Mike
    ANNALS OF MEDICINE AND SURGERY, 2024, 86 (10): : 6300 - 6302
  • [6] High-dose methylprednisolone with chemotherapy for invasive thymoma: A case report
    Hayashi, Mitsutoshi
    Taira, Manako
    Yamawaki, Isao
    Ohkawa, Shin-Ichiro
    ANTICANCER RESEARCH, 2006, 26 (5B) : 3645 - 3648
  • [7] HIGH-DOSE METHYLPREDNISOLONE IN A PORCINE MODEL OF ARDS INDUCED BY ENDOTOXEMIA
    MODIG, J
    BORG, T
    ACTA CHIRURGICA SCANDINAVICA, 1985, : 94 - 103
  • [8] High-dose methylprednisolone-containing chemotherapy in advanced invasive thymoma--report of three cases
    Suda T.
    Sugimura S.
    Hattori Y.
    Sugimura H.
    Kobayashi Y.
    Hoshino R.
    The Japanese Journal of Thoracic and Cardiovascular Surgery, 1998, 46 (1): : 115 - 120
  • [9] Persistent hiccups induced by high-dose methylprednisolone in optic neuritis
    Genc, G.
    Bek, S.
    Kasikci, T.
    Koc, G.
    Demirkaya, S.
    Odabasi, Z.
    JOURNAL OF NEUROLOGY, 2010, 257 : S80 - S80
  • [10] Optimal Prevention of Seizures Induced by High-Dose Busulfan
    Eberly, Andrea L.
    Anderson, Gail D.
    Bubalo, Joseph S.
    McCune, Jeannine S.
    PHARMACOTHERAPY, 2008, 28 (12): : 1502 - 1510
12345