OPTIMIZATION OF INFLUENZA A AND B VIRUSES CULTIVATION CONDITIONS FOR PREPARATION OF TRIVALENT SEASONAL INFLUENZA SPLIT VACCINE

被引：0

作者：

Akzhunusova, Indira ^{[1
]}

Assanzhanova, Nurika ^{[1
]}

Tabynov, Kaissar ^{[1
]}

Abdrakhmanova, Buryl ^{[2
]}

Sansyzbay, Abilai ^{[1
]}

机构：

[1] Res Inst Biol Safety Problems, Gvardeisky 080409, Kazakhstan

[2] Kyrgyz State Univ, Bishkek, Kyrgyzstan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2015年 / 6卷 / 06期

关键词：

Influenza A and B viruses; cultivation conditions; chicken embryos; seasonal influenza vaccine;

D O I：

10.13040/IJPSR.0975-8232.6(6).2375-81

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article presents the results of studies on determination of optimal parameters of recombinant strains A/NYMC X-217 (H3N2) and B/NYMC BX-49 of influenza virus cultivation in chicken embryos. It is found that a maximum virus accumulation is formed under the following cultivation conditions: age of chicken embryos is 9-11 days in case of inoculation of the allantoic cavity, inoculated virus dose - 1,000-10,000 EID50, temperature and time of incubation - (34 +/- 0.5) degrees C and 48 h, respectively. If the cultivation parameters are satisfied, it is possible to obtain a highly active viruscontaining material with infectious and hemagglutinating activity, as well as a content of hemagglutinin not less than 7.0lg EID50/ml, 1: 256 and 7.0 mu g/ml, respectively, that is enough to prepare a trivalent inactive seasonal influenza split vaccine.

引用

页码：2375 / 2381

页数：7

共 50 条

[41] Inactivated Split-Virion Seasonal Influenza Vaccine (Fluarix®) A Review of its Use in the Prevention of Seasonal Influenza in Adults and the Elderly
Curran, Monique P.
Leroux-Roels, Isabel
DRUGS, 2010, 70 (12) : 1519 - 1543
[42] Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults
Stevanovic, Goran
Lavadinovic, Lidija
Vignjevic, Svetlana Filipovic
Holt, Renee
Ilic, Katarina
Scorza, Francesco Berlanda
Sparrow, Erin
Stoiljkovic, Vera
Torelli, Guido
Madenwald, Tamra
Socquet, Muriel
Barac, Aleksandra
Ilieva-Borisova, Yordanka
Pelemis, Mijomir
Flores, Jorge
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2018, 14 (03) : 579 - 586
[43] TRIAL OF SPLIT-PRODUCT TRIVALENT INFLUENZA VACCINE IN HIGH-RISK CHILDREN
YAMADA, A
YAMAWAKI, H
TSUDA, N
BABA, K
YABUUCHI, H
MAEDA, A
YAMANISHI, K
BIKEN JOURNAL, 1982, 25 (02) : 89 - 95
[44] Chasing Seasonal Influenza - The Need for a Universal Influenza Vaccine
Paules, Catharine I.
Sullivan, Sheena G.
Subbarao, Kanta
Fauci, Anthony S.
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (01): : 7 - 9
[45] Influenza vaccination in adults with asthma: Safety of an inactivated trivalent influenza vaccine
Kmiecik, T.
Arnoux, Sabine
Kobryn, Aleksandra
Gorski, Pawel
JOURNAL OF ASTHMA, 2007, 44 (10) : 817 - 822
[46] Virological perspectives and characterization of seasonal influenza B viruses in Mumbai
Gohil, Devanshi
Kothari, Sweta
Correa, Daphne
Deshmukh, Ranjana
Chowdhary, Abhay
CURRENT SCIENCE, 2016, 110 (05): : 823 - 827
[47] The seasonal influenza vaccine Agriflu®
Vajo, Zoltan
EXPERT REVIEW OF VACCINES, 2011, 10 (11) : 1513 - 1517
[48] An annual vaccine: Seasonal influenza
Jivapaisarnpong, Teeranart
Krause, Philip R.
BIOLOGICALS, 2009, 37 (06) : 410 - 411
[49] The effectiveness of seasonal trivalent inactivated influenza vaccine in preventing laboratory confirmed influenza hospitalisations in Auckland, New Zealand in 2012
Turner, Nikki
Pierse, Nevil
Bissielo, Ange
Huang, Q. Sue
Baker, Michael G.
Widdowson, Marc-Alain
Kelly, Heath
VACCINE, 2014, 32 (29) : 3687 - 3693
[50] Inactivated Quadrivalent Split-Virus Seasonal Influenza Vaccine (Fluarix® Quadrivalent): A Review of Its Use in the Prevention of Disease Caused by Influenza A and B
Kate McKeage
Drugs, 2013, 73 : 1587 - 1594

← 1 2 3 4 5 →