EFFECT OF PARTICLE-SIZE OF DRIED MYCOBACTERIA ON ADJUVANT INDUCED ARTHRITIS IN THE RAT

被引：6
|
作者：
BEST, R [1 ]
CHRISTIAN, R [1 ]
LEWIS, DA [1 ]
机构：
[1] UNIV ASTON, DEPT PHARM, PHARMACOL LABS, BIRMINGHAM B4 7ET, W MIDLANDS, ENGLAND
来源：
AGENTS AND ACTIONS | 1984年 / 14卷 / 02期
关键词：
D O I：
10.1007/BF01966651
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Freund''s complete adjuvant prepared by grinding dried, heat-killed Mycobacterium tuberculosis with liquid paraffin was investigated for particle size-weight distribution. Variations in the grinding times and preparative procedure had a marked effect on the arthritogenic action of the adjuvant in the rat. A satisfactory response in the injected foot was found only when the particle size was < 19 .mu.m; a secondary response in the non-injected foot required particles < 10 .mu.m in diameter.
引用
收藏
页码：265 / 268
页数：4
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