EFFECT OF PARTICLE-SIZE OF DRIED MYCOBACTERIA ON ADJUVANT INDUCED ARTHRITIS IN THE RAT

被引：6

作者：

BEST, R ^{[1
]}

CHRISTIAN, R ^{[1
]}

LEWIS, DA ^{[1
]}

机构：

[1] UNIV ASTON, DEPT PHARM, PHARMACOL LABS, BIRMINGHAM B4 7ET, W MIDLANDS, ENGLAND

来源：

AGENTS AND ACTIONS | 1984年 / 14卷 / 02期

关键词：

D O I：

10.1007/BF01966651

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Freund''s complete adjuvant prepared by grinding dried, heat-killed Mycobacterium tuberculosis with liquid paraffin was investigated for particle size-weight distribution. Variations in the grinding times and preparative procedure had a marked effect on the arthritogenic action of the adjuvant in the rat. A satisfactory response in the injected foot was found only when the particle size was < 19 .mu.m; a secondary response in the non-injected foot required particles < 10 .mu.m in diameter.

引用

页码：265 / 268

页数：4

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