FLUCONAZOLE RESISTANCE IN CANDIDA-GLABRATA

被引：188

作者：

HITCHCOCK, CA ^{[1
]}

PYE, GW ^{[1
]}

TROKE, PF ^{[1
]}

JOHNSON, EM ^{[1
]}

WARNOCK, DW ^{[1
]}

机构：

[1] BRISTOL ROYAL INFIRM & GEN HOSP,DEPT MICROBIOL,BRISTOL BS2 8HW,AVON,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 09期

关键词：

D O I：

10.1128/AAC.37.9.1962

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14alpha-sterol demethylase (P-450DM) in lysates of cells from both susceptible and resistant cultures (50% inhibitory concentration, 0.2 muM), indicating that resistance was unrelated to changes in P-450DM. Instead, it appeared to arise from a permeability barrier to fluconazole, since resistant cells were unable to take up radiolabelled drug.

引用

页码：1962 / 1965

页数：4

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