FLUCONAZOLE RESISTANCE IN CANDIDA-GLABRATA

被引：188

作者：

HITCHCOCK, CA ^{[1
]}

PYE, GW ^{[1
]}

TROKE, PF ^{[1
]}

JOHNSON, EM ^{[1
]}

WARNOCK, DW ^{[1
]}

机构：

[1] BRISTOL ROYAL INFIRM & GEN HOSP,DEPT MICROBIOL,BRISTOL BS2 8HW,AVON,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 09期

关键词：

D O I：

10.1128/AAC.37.9.1962

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14alpha-sterol demethylase (P-450DM) in lysates of cells from both susceptible and resistant cultures (50% inhibitory concentration, 0.2 muM), indicating that resistance was unrelated to changes in P-450DM. Instead, it appeared to arise from a permeability barrier to fluconazole, since resistant cells were unable to take up radiolabelled drug.

引用

页码：1962 / 1965

页数：4

共 50 条

[21] CHARACTERIZATION OF AN AZOLE-RESISTANT CANDIDA-GLABRATA ISOLATE
VANDENBOSSCHE, H
MARICHAL, P
ODDS, FC
LEJEUNE, L
COENE, MC
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (12) : 2602 - 2610
[22] Effects of Pdr1 Phosphorylation on Fluconazole Resistance in Candida glabrata
Stapleton, Abby
Breen, Meghan
PROTEIN SCIENCE, 2023, 32 (12)
[23] COMPARISON OF FLUCONAZOLE, AMPHOTERICIN-B AND FLUCYTOSINE IN TREATMENT OF A MURINE MODEL OF DISSEMINATED INFECTION WITH CANDIDA-GLABRATA IN IMMUNOCOMPROMISED MICE
ATKINSON, BA
BOUTHET, C
BOCANEGRA, R
CORREA, A
LUTHER, MF
GRAYBILL, JR
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1995, 35 (05) : 631 - 640
[24] CANDIDA-GLABRATA METALLOTHIONEINS - CLONING AND SEQUENCE OF THE GENES AND CHARACTERIZATION OF PROTEINS
MEHRA, RK
GAREY, JR
BUTT, TR
GRAY, WR
WINGE, DR
JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (33) : 19747 - 19753
[25] DISRUPTION ANALYSIS OF METALLOTHIONEIN-ENCODING GENES IN CANDIDA-GLABRATA
MEHRA, RK
THORVALDSEN, JL
MACREADIE, IG
WINGE, DR
GENE, 1992, 114 (01) : 75 - 80
[26] MECHANISMS OF MT-II(A) GENE AMPLIFICATION IN CANDIDA-GLABRATA
HUNTER, TC
MEHRA, RK
FASEB JOURNAL, 1993, 7 (07): : A1292 - A1292
[27] Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production
Samaranayake, Y. H.
Cheung, B. P. K.
Wang, Y.
Yau, J. Y. Y.
Yeung, K. W. S.
Samaranayake, L. P.
JOURNAL OF MEDICAL MICROBIOLOGY, 2013, 62 : 303 - 318
[28] Evaluation of four calcium channel blockers as fluconazole resistance inhibitors in Candida glabrata
Alnajjar, Lina M.
Bulatova, Nailya R.
Darwish, Rula M.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2018, 14 : 185 - 189
[29] HETEROLOGOUS GENE-EXPRESSION AND PROTEIN SECRETION FROM CANDIDA-GLABRATA
MACREADIE, IG
CASTELLI, LA
MEHRA, RK
THORVALDSEN, JL
WINGE, DR
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 1994, 19 : 265 - 269
[30] SELECTIVE AND TANDEM AMPLIFICATION OF A MEMBER OF THE METALLOTHIONEIN GENE FAMILY IN CANDIDA-GLABRATA
MEHRA, RK
GAREY, JR
WINGE, DR
JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (11) : 6369 - 6375

← 1 2 3 4 5 →