RAPIDLY PROGRESSING ATROPHY OF MEDIAL TEMPORAL-LOBE IN ALZHEIMERS-DISEASE

被引：191
|
作者：
JOBST, KA
SMITH, AD
SZATMARI, M
ESIRI, MM
JASKOWSKI, A
HINDLEY, N
MCDONALD, B
MOLYNEUX, AJ
机构：
[1] UNIV OXFORD,DEPT PHARMACOL,OXFORD PROJECT INVESTIGATE MEMORY & AGEING,OXFORD OX1 3QT,ENGLAND
[2] UNIV OXFORD,DEPT CLIN NEUROL,OXFORD OX1 3QT,ENGLAND
[3] RADCLIFFE INFIRM,DEPT NEUROPATHOL,OXFORD OX2 6HE,ENGLAND
[4] RADCLIFFE INFIRM,DEPT NEURORADIOL,OXFORD OX2 6HE,ENGLAND
来源：
LANCET | 1994年 / 343卷 / 8901期
关键词：
D O I：
10.1016/S0140-6736(94)92028-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The symptoms of Alzheimer's disease are associated with pathological change and loss of neurons in the medial temporal lobe. By yearly temporal-lobe-oriented computed tomograms the average rate of atrophy of the medial temporal lobe was 15.1% per year (95% CI 10.0, 20.2) in 20 patients with histopathologically, confirmed Alzheimer's disease and 1.5% (0.2, 2.8) in 47 healthy ageing controls. Such excessive atrophy presumably reflects the vulnerability of the medial temporal lobe to a catastrophic event, probably a pathological cascade process. Thus, Alzheimer's disease may not be due simply to an acceleration of normal ageing but, rather, is the consequence of a true disease process.
引用
收藏
页码：829 / 830
页数：2
相关论文
共 50 条
  • [21] TEMPORAL-LOBE REGIONS ON MAGNETIC-RESONANCE-IMAGING IDENTIFY PATIENTS WITH EARLY ALZHEIMERS-DISEASE
    KILLIANY, RJ
    MOSS, MB
    ALBERT, MS
    SANDOR, T
    TIEMAN, J
    JOLESZ, F
    ARCHIVES OF NEUROLOGY, 1993, 50 (09) : 949 - 954
  • [22] THE CERAD EXPERIENCE .8. NEUROIMAGING NEUROPATHOLOGY CORRELATES OF TEMPORAL-LOBE CHANGES IN ALZHEIMERS-DISEASE
    DAVIS, PC
    GEARING, M
    GRAY, L
    MIRRA, SS
    MORRIS, JC
    EDLAND, SD
    LIN, T
    HEYMAN, A
    NEUROLOGY, 1995, 45 (01) : 178 - 179
  • [23] QUANTIFICATION OF BETA-A4 PROTEIN DEPOSITION IN THE MEDIAL TEMPORAL-LOBE - A COMPARISON OF ALZHEIMERS-DISEASE AND SENILE DEMENTIA OF THE LEWY BODY TYPE
    GENTLEMAN, SM
    WILLIAMS, B
    ROYSTON, MC
    JAGOE, R
    CLINTON, J
    PERRY, RH
    INCE, PG
    ALLSOP, D
    POLAK, JM
    ROBERTS, GW
    NEUROSCIENCE LETTERS, 1992, 142 (01) : 9 - 12
  • [24] ANATOMY OF THE MEDIAL TEMPORAL-LOBE
    VANHOESEN, GW
    MAGNETIC RESONANCE IMAGING, 1995, 13 (08) : 1047 - 1055
  • [25] DEVELOPMENTAL ABNORMALITIES OF THE MEDIAL TEMPORAL-LOBE IN PATIENTS WITH TEMPORAL-LOBE EPILEPSY
    LEHERICY, S
    DORMONT, D
    SEMAH, F
    CLEMENCEAU, S
    GRANAT, O
    MARSAULT, C
    BAULAC, M
    AMERICAN JOURNAL OF NEURORADIOLOGY, 1995, 16 (04) : 617 - 626
  • [26] The medial temporal-lobe atrophy index relates to memory impairment in early Alzheimer's disease
    Alvarez-Avellon, T.
    Lopez-Muniz, A.
    Vega, J. A.
    Menendez Gonzalez, M.
    JOURNAL OF NEUROLOGY, 2014, 261 : S259 - S260
  • [27] The medial temporal-lobe atrophy index relates to memory impairment in early Alzheimer's disease
    Alvarez-Avellon, T.
    Lopez-Muniz, A.
    Vega, J. A.
    Menendez Gonzalez, M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2014, 21 : 388 - 388
  • [28] THE TEMPORAL-LOBE IN DEMENTIA OF ALZHEIMERS TYPE
    WILCOCK, GK
    GERONTOLOGY, 1983, 29 (05) : 320 - 324
  • [29] A COMPARISON OF BETA-AMYLOID (AP) DEPOSITION IN THE MEDIAL TEMPORAL-LOBE IN LATE-ONSET SPORADIC ALZHEIMERS-DISEASE, AND DOWNS-SYNDROME
    ARMSTRONG, RA
    AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 1995, 2 (02): : 107 - 113
  • [30] CATEGORY-SPECIFIC SEMANTIC IMPAIRMENT IN ALZHEIMERS-DISEASE AND TEMPORAL-LOBE DYSFUNCTION - A COMPARATIVE-STUDY
    MAURI, A
    DAUM, I
    SARTORI, G
    RIESCH, G
    BIRBAUMER, N
    JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1994, 16 (05) : 689 - 701
12345