RAPIDLY PROGRESSING ATROPHY OF MEDIAL TEMPORAL-LOBE IN ALZHEIMERS-DISEASE

被引：191
|
作者：
JOBST, KA
SMITH, AD
SZATMARI, M
ESIRI, MM
JASKOWSKI, A
HINDLEY, N
MCDONALD, B
MOLYNEUX, AJ
机构：
[1] UNIV OXFORD,DEPT PHARMACOL,OXFORD PROJECT INVESTIGATE MEMORY & AGEING,OXFORD OX1 3QT,ENGLAND
[2] UNIV OXFORD,DEPT CLIN NEUROL,OXFORD OX1 3QT,ENGLAND
[3] RADCLIFFE INFIRM,DEPT NEUROPATHOL,OXFORD OX2 6HE,ENGLAND
[4] RADCLIFFE INFIRM,DEPT NEURORADIOL,OXFORD OX2 6HE,ENGLAND
来源：
LANCET | 1994年 / 343卷 / 8901期
关键词：
D O I：
10.1016/S0140-6736(94)92028-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The symptoms of Alzheimer's disease are associated with pathological change and loss of neurons in the medial temporal lobe. By yearly temporal-lobe-oriented computed tomograms the average rate of atrophy of the medial temporal lobe was 15.1% per year (95% CI 10.0, 20.2) in 20 patients with histopathologically, confirmed Alzheimer's disease and 1.5% (0.2, 2.8) in 47 healthy ageing controls. Such excessive atrophy presumably reflects the vulnerability of the medial temporal lobe to a catastrophic event, probably a pathological cascade process. Thus, Alzheimer's disease may not be due simply to an acceleration of normal ageing but, rather, is the consequence of a true disease process.
引用
收藏
页码：829 / 830
页数：2
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