Separation of Etoricoxib and Its Degradation Products in Drug Substance Using UPLC (TM)

被引：6
|
作者：
Vora, Dinesh N. [1 ]
Kadav, Arun A.
机构：
[1] Mithibai Coll Arts, Chauhan Inst Sci, Chem Dept, Viile Parle W, Bombay 400056, Maharashtra, India
来源：
EURASIAN JOURNAL OF ANALYTICAL CHEMISTRY | 2007年 / 2卷 / 03期
关键词：
Etoricoxib; degradation products; UPLC; validation;
D O I：
10.12973/ejac.2007.00019a
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A UPLC (TM) method was developed and validated for the separation of Etoricoxib and its degradation products in drug substance. The main drug and its seven major and few minor degradation products were well separated within seven minutes on acquity UPLC (TM) BEH C18 column (1.7 mu, 2.1 x 100 mm) maintained at 25 degrees C, using 0.01M acetate buffer pH 5.0 - acetonitrile (60 : 40, v/v) as mobile phase. The flow rate was 0.3 mL.min(-1) and observed backpressure was about 10500 psi. Detection was performed at 235 nm using PDA detector. Linearity was obtained in the concentration range of 0.05 - 120 mu g.mL(-1). The method was validated for precision, linearity, LOD and LOQ. Stability indicating capability was established by forced degradation experiments.
引用
收藏
页码：151 / 158
页数：8
相关论文
共 50 条
  • [31] A Validated UPLC Method Used for the Determination of Trandolapril and its Degradation Products as per ICH Guidelines
    Sahu, Kapendra
    Karthikeyan, Chandrabose
    Moorthy, Narayana S. H. N.
    Trivedi, Piyush
    CURRENT PHARMACEUTICAL ANALYSIS, 2011, 7 (03) : 182 - 188
  • [32] Iron (III)-mediated degradation of α-asarone and characterization of its major degradation products by UPLC-MS/MS and NMR
    Zhong, Sihui
    Zhang, Keke
    Shen, Linhong
    Jin, Xiangfei
    Chen, Rong
    Shen, Weiyang
    PHARMAZIE, 2021, 76 (12): : 588 - 593
  • [33] Separation and identification of neuropeptide Y, two of its fragments and their degradation products using capillary electrophoresis mass spectrometry
    Ensing, K
    de Boer, T
    Schreuder, N
    de Zeeuw, RA
    JOURNAL OF CHROMATOGRAPHY B, 1999, 727 (1-2): : 53 - 61
  • [34] Separation of imidacloprid and its degradation products using reversed phase liquid chromatography with water rich mobile phases
    Ding, Tao
    Lavine, Barry K.
    JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (51) : 9221 - 9226
  • [35] New Rapid Stability indicating RP-UPLC Method for the Determination of Olaparib, its Related Substances and Degradation Products in Bulk drug and Dosage Form
    Kavitapu, DasameswaraRao
    Maruthapillai, Arthanareeswari
    Devikala, S.
    Selvi, Arockia J.
    Tamilselvi, M.
    Mahapatra, Sudarshan
    Kumar, Pradeep G.
    Tyagi, Pradeep Kumar
    MATERIALS TODAY-PROCEEDINGS, 2019, 14 : 492 - 503
  • [36] SEPARATION OF PERMETHRIN AND SOME OF ITS DEGRADATION PRODUCTS BY HIGHPERFORMANCE LIQUID-CHROMATOGRAPHY
    LAM, S
    GRUSHKA, E
    JOURNAL OF CHROMATOGRAPHY, 1978, 154 (02): : 318 - 320
  • [37] HPLC-METHODS FOR SEPARATION AND QUANTITATION OF RESERPIN AND ITS MAIN DEGRADATION PRODUCTS
    DARGEL, E
    MIELCK, JB
    JOURNAL OF LIQUID CHROMATOGRAPHY, 1990, 13 (20): : 3973 - 3984
  • [38] SEPARATION AND QUANTITATION OF POSSIBLE DEGRADATION PRODUCTS OF PROCARBAZINE HYDROCHLORIDE IN ITS DOSAGE FORM
    BURCE, GL
    BOEHLERT, JP
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (03) : 424 - 426
  • [39] UPLC Method for Determination of Moxonidine and Its Degradation Products in Active Pharmaceutical Ingredient and Pharmaceutical Dosage Form
    Otasevic, Biljana
    Milovanovic, Svetlana
    Zecevic, Mira
    Golubovic, Jelena
    Protic, Ana
    CHROMATOGRAPHIA, 2014, 77 (1-2) : 109 - 118
  • [40] UPLC Method for Determination of Moxonidine and Its Degradation Products in Active Pharmaceutical Ingredient and Pharmaceutical Dosage Form
    Biljana Otašević
    Svetlana Milovanović
    Mira Zečević
    Jelena Golubović
    Ana Protić
    Chromatographia, 2014, 77 : 109 - 118
12345