THE PROTECTIVE ROLE OF HUMORAL NEUTRALIZING ANTIBODY IN THE NIH POTENCY TEST FOR RABIES VACCINES

被引：36

作者：

WUNDERLI, PS ^{[1
]}

SHADDOCK, JH ^{[1
]}

SCHMID, DS ^{[1
]}

MILLER, TJ ^{[1
]}

BAER, GM ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM ANIM HLTH,KING OF PRUSSIA,PA 19406

来源：

VACCINE | 1991年 / 9卷 / 09期

关键词：

RABIES; HUMORAL NEUTRALIZING ANTIBODY; NIH POTENCY TEST; MICE;

D O I：

10.1016/0264-410X(91)90188-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.

引用

页码：638 / 642

页数：5

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