THE PROTECTIVE ROLE OF HUMORAL NEUTRALIZING ANTIBODY IN THE NIH POTENCY TEST FOR RABIES VACCINES

被引：36
|
作者：
WUNDERLI, PS [1 ]
SHADDOCK, JH [1 ]
SCHMID, DS [1 ]
MILLER, TJ [1 ]
BAER, GM [1 ]
机构：
[1] SMITHKLINE BEECHAM ANIM HLTH,KING OF PRUSSIA,PA 19406
来源：
VACCINE | 1991年 / 9卷 / 09期
关键词：
RABIES; HUMORAL NEUTRALIZING ANTIBODY; NIH POTENCY TEST; MICE;
D O I：
10.1016/0264-410X(91)90188-C
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.
引用
收藏
页码：638 / 642
页数：5
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