IMMUNOCYTOCHEMICAL LOCALIZATION OF TRANSFORMING GROWTH-FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN FALLOPIAN-TUBES AND CUMULUS CELLS

被引：17
|
作者：
ELDANASOURI, I [1 ]
FRANCES, A [1 ]
WESTPHAL, LM [1 ]
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT GYNECOL & OBSTET,STANFORD,CA 94305
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1993年 / 30卷 / 2-3期
关键词：
GROWTH FACTORS; EMBRYONIC DEVELOPMENT; AUTOCRINE;
D O I：
10.1111/j.1600-0897.1993.tb00606.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
PROBLEM: Transforming growth factor-alpha (TGF-alpha) has been shown to be a potent stimulant of oocyte maturation and embryonic development. The role of maternal growth factors and their mechanism of action in early mammalian development is not well understood. METHOD: In this study, the presence of TGF-alpha and epidermal growth factor receptor (EGF-R) in human cumulus cells and fallopian tubes was investigated by immunocytochemical techniques. RESULTS: The fallopian tube showed intense staining for TGF-alpha in the apical region of the epithelial cells, and the cumulus cells showed intense staining for EGF-R on cell membranes. CONCLUSION: The presence of TGF-alpha in the fallopian tube epithelium and its receptor on cumulus cells suggest a paracrine mechanism between maternal growth factors and the developing embryo.
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页码：82 / 87
页数：6
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